Oncolytic viruses in cancer therapy
| Autor: | Markus Vähä-Koskela, Jari E. Heikkilä, Ari Hinkkanen |
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| Rok vydání: | 2006 |
| Předmět: |
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Vaccinia virus Cancer Research viruses Virus Replication Neoplasms FMG fusogenic membrane glycoprotein HSV herpes simplex type 1 virus i.c. intracranial Oncolytic MOI multiplicity of infection TAA tumor associated antigen Oncolytic Virotherapy Replication-competent biology Cancer gene therapy Replication-deficient i.p. intraperitoneal Sendai virus ECM extracellular matrix HIV human immunodeficiency virus Oncolytic Viruses Oncology Vesicular stomatitis virus VSV vesicular stomatitis virus TK thymidine kinase Myxoma virus Semliki Forest virus CNS central nervous system Virus Article PKR protein kinase R (Mo)MLV (Moloney) murine leukemia virus i.v. intravenous Animals Humans WT wildtype IFN interferon Virotherapy VLP viral-like particle Virus-resistant i.t. intratumoral Genetic Therapy biology.organism_classification Virology Oncolytic virus Disease Models Animal Viral replication NDV Newcastle disease virus SFV Semliki Forest virus PFU plaque-forming unit |
| Zdroj: | Cancer Letters |
| ISSN: | 0304-3835 |
| Popis: | Oncolytic virotherapy is a promising form of gene therapy for cancer, employing nature's own agents to find and destroy malignant cells. The purpose of this review is to provide an introduction to this very topical field of research and to point out some of the current observations, insights and ideas circulating in the literature. We have strived to acknowledge as many different oncolytic viruses as possible to give a broader picture of targeting cancer using viruses. Some of the newest additions to the panel of oncolytic viruses include the avian adenovirus, foamy virus, myxoma virus, yaba-like disease virus, echovirus type 1, bovine herpesvirus 4, Saimiri virus, feline panleukopenia virus, Sendai virus and the non-human coronaviruses. Although promising, virotherapy still faces many obstacles that need to be addressed, including the emergence of virus-resistant tumor cells. |
| Databáze: | OpenAIRE |
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