Diagnostic accuracy of serum endothelin-1 in patients with HCC on top of liver cirrhosis

Autor:	Emad F. Mohammad, Mohammad M. Elbadry, Mina Tharwat, Ehab F. Abdo
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine medicine.medical_specialty Cirrhosis lcsh:Surgery Physical examination Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Positive predicative value medicine Medical history HCC lcsh:RC799-869 General Environmental Science medicine.diagnostic_test Endothelin-1 business.industry lcsh:RD1-811 Hepatology medicine.disease digestive system diseases Portal vein thrombosis 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Hepatocellular carcinoma General Earth and Planetary Sciences Abdomen lcsh:Diseases of the digestive system. Gastroenterology business Prediction
Zdroj:	Egyptian Liver Journal, Vol 10, Iss 1, Pp 1-7 (2020)
ISSN:	2090-6226
Popis:	Background Hepatocellular carcinoma (HCC) is one of the most common cancers and one of the main causes of cancer-related deaths. As the overall survival of patients with cirrhosis has improved and the global incidence of HCC has continued to increase, strategies for the early detection of HCC are urgently needed for better prognosis. In this study, we aimed to assess the accuracy of endothelin-1 in the diagnosis of HCC in cirrhotic patients in comparison with alpha-fetoprotein (AFP) and whether it could predict its vascular spread. This is a case–control study that included 70 cirrhotic patients with or without hepatocellular carcinoma. Patients were subjected to complete medical history taking, clinical examination and laboratory investigations including serum endothelin-1, alpha-fetoprotein, abdominal ultrasound and Triphasic multi-slice computed tomography (CT; abdomen and pelvis). The outcome results obtained for endothelin-1 were used to assess its diagnostic accuracy in HCC diagnosis and the prediction of presence of vascular spread. Results There was a statistically significant increase in serum endothelin-1 in HCC in comparison to cirrhotic patients and normal persons (P value P value = 0.547). Conclusion Endothelin-1 has high sensitivity and specificity for diagnosis of hepatocellular carcinoma. However, it has little value for prediction of its vascular spread.
Databáze:	OpenAIRE
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