Malondialdehyde, lipoprotein-a, lipoprotein ratios, comprehensive lipid tetrad index and atherogenic index as surrogate markers for cardiovascular disease in patients with psoriasis: a case–control study
Autor: | Pushpinder S Chauhan, Vikram K Mahajan, Anuj Sharma, Dhaarna Wadhwa, Rajinder S Yadav, Satya Bhushan, Aditi Sharma, Shailja Chauhan, Karaninder S Mehta, Vikas Sharma |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male Risk medicine.medical_specialty India Dermatology Gastroenterology Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Malondialdehyde Internal medicine Psoriasis medicine Humans Risk factor Aged Framingham Risk Score biology business.industry General Medicine Lipoprotein(a) Middle Aged Prognosis medicine.disease Lipids Cardiovascular Diseases Case-Control Studies 030220 oncology & carcinogenesis Disease Progression biology.protein Female Metabolic syndrome business Biomarkers Dyslipidemia Lipoprotein |
Zdroj: | Archives of Dermatological Research. 311:287-297 |
ISSN: | 1432-069X 0340-3696 |
Popis: | Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atherogenic index (AI), and evaluated cardiovascular risk in 132 (M:F 94:38) patients with psoriasis aged 20–79 years with chronic plaque psoriasis and equal number of age and gender-matched controls. Lipoprotein ratios, CLTI and AI were calculated using standard formulae. Cardiovascular 10-year risk was graded by Framingham risk score (FRS) as low, intermediate and severe. Mild-to-moderate and severe psoriasis was present in 125 (94.7%), and 7 (5.3%) patients, respectively, and 19 (14.39%) patients had psoriatic arthritis. Statistically significant differences were noted for LDL, LDL/HDL, non-HDL/HDL, MDA, LP-a, AI and CLTI. There was a significantly positive correlation between PASI with LP-a (p = 0.003, r = 0.25) and AI (p = 0.012, r = 0.22). Serum levels of MDA correlated positively with LP-a (p |
Databáze: | OpenAIRE |
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