Time after ostomy surgery and type of treatment are associated with quality of life changes in colorectal cancer patients with colostomy

Autor: Arenamoline Xavier Duarte, Karine de Almeida Silva, Lúcio Borges de Araújo, Amanda Rodrigues Cruz, Geórgia das Graças Pena
Rok vydání: 2020
Předmět:
Male
Colorectal cancer
medicine.medical_treatment
Health Status
Cancer Treatment
0302 clinical medicine
Quality of life
Colostomy
Medicine and Health Sciences
030212 general & internal medicine
Prospective Studies
Multidisciplinary
Pharmaceutics
Chemoradiotherapy
Middle Aged
Oncology
030220 oncology & carcinogenesis
Vomiting
Medicine
Female
medicine.symptom
Colorectal Neoplasms
Research Article
Clinical Oncology
medicine.medical_specialty
Nausea
Science
Ostomy
Radiation Therapy
Surgical and Invasive Medical Procedures
03 medical and health sciences
Digestive System Procedures
Cancer Chemotherapy
Bloating
Drug Therapy
medicine
Humans
Chemotherapy
Aged
Colorectal Cancer
business.industry
Cancer
Cancers and Neoplasms
medicine.disease
Surgery
Health Care
Quality of Life
Clinical Medicine
business
Combination Chemotherapy
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0239201 (2020)
ISSN: 1932-6203
Popis: Purpose Quality of life in colorectal cancer patients may be affected by colostomy and treatment, but relevant studies are still scarce and contradictory. The present study aimed to evaluate the association between colostomy time and treatment type with quality of life in colorectal cancer patients. Methods A prospective observational study of 41 patients with colorectal cancer was conducted on three occasions T0, T1 and T2 (0–2; 3–5 and 6–8 months after ostomy surgery, respectively). The treatments prescribed were: surgery alone, chemotherapy or radiotherapy, or chemoradiotherapy. European Organization for Research and Treatment of Cancer questionnaires were used to evaluate quality of life. Worsening clinical changes were evaluated considering difference in scores between times of surgery ≥±9 points. Results Regarding ostomy surgery, scores in physical function improved between T0 and T1 and these better scores were maintained at T1 to T2. The same was observed for urinary frequency, appetite loss and dry mouth. Chemoradiotherapy was associated with worse scores for global health status, nausea and vomiting, bloating and dry mouth. Although significant differences were not observed in some domains in the Generalized Estimating Equations analysis, patients showed noticeable changes for the worse in the pain, anxiety, weight concern, flatulence and embarrassment domains during these periods. Conclusions Colostomy improved quality of life at 3–5 months in most domains of quality of life and remained better at 6–8 months after surgery. Chemoradiotherapy had a late negative influence on quality of life. Health teams could use these results to reassure patients that this procedure will improve their quality of life in many functional and symptomatic aspects.
Databáze: OpenAIRE
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