Associations of Urinary Cadmium with Age and Urinary Proteins: Further Evidence of Physiological Variations Unrelated to Metal Accumulation and Toxicity
| Autor: | Harry Roels, Vincent Haufroid, Agnès Chaumont, Lutgarde Thijs, Isabella Annesi-Maesano, Jan A. Staessen, Gladys Deumer, Alfred Bernard, Catherine Voisin |
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| Přispěvatelé: | Université Catholique de Louvain = Catholic University of Louvain (UCL), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Maastricht University [Maastricht], HAL UPMC, Gestionnaire |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Urinalysis
Health Toxicology and Mutagenesis Urinary system chemistry.chemical_element [SDV.TOX.TCA]Life Sciences [q-bio]/Toxicology/Toxicology and food chain 010501 environmental sciences 01 natural sciences 03 medical and health sciences chemistry.chemical_compound medicine [SDV.EE.SANT] Life Sciences [q-bio]/Ecology environment/Health 030304 developmental biology 0105 earth and related environmental sciences [SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health 0303 health sciences Cadmium Creatinine medicine.diagnostic_test Research Public Health Environmental and Occupational Health 3. Good health Retinol binding protein [SDV.TOX.TCA] Life Sciences [q-bio]/Toxicology/Toxicology and food chain chemistry Toxicity Immunology Biomarker (medicine) Risk assessment |
| Zdroj: | Environmental Health Perspectives Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2013, 121 (9), pp.1047-1053. ⟨10.1289/ehp.1306607⟩ Environmental Health Perspectives, 2013, 121 (9), pp.1047-1053. ⟨10.1289/ehp.1306607⟩ |
| ISSN: | 0091-6765 1552-9924 |
| DOI: | 10.1289/ehp.1306607⟩ |
| Popis: | Background: The current risk assessment for environmental cadmium (Cd) largely relies on the assumption that urinary Cd (U-Cd) is a reliable biomarker of the Cd body burden. Recent studies have questioned the validity of this assumption. Objectives: We studied the lifetime trend of U-Cd as a function of diuresis, gender, smoking status, and protein tubular reabsorption. We also analyzed the associations between U-Cd and urinary proteins. Methods: Cd, retinol-binding protein, and albumin were measured in the urine of six cohorts of the general population of Belgium, with a mean age ranging from 5.7 to 88.1 years (n = 1,567). Variations of U-Cd with age were modeled using natural cubic splines. Results: In both genders, U-Cd decreased to a minimum (~ 0.20 μg/L) at the end of adolescence, then increased until 60–70 years of age (~ 0.60 μg/L in never-smokers) before leveling off or decreasing. When U-Cd was expressed in micrograms per gram of creatinine, these variations were amplified (minimum, 0.15 µg/g creatinine; maximum, 0.70 µg/g creatinine) and much higher U-Cd values were observed in women. We observed no difference in U-Cd levels between never-smokers and former smokers, and the difference with current smokers did not increase over time. Lifetime curves of U-Cd were higher with increasing urinary retinol-binding protein or albumin, a consequence of the coexcretion of Cd with proteins. Conclusions: At low Cd exposure levels, U-Cd and age are associated through nonlinear and nonmonotonic relationships that appear to be driven mainly by recent Cd intake and physiological variations in the excretion of creatinine and proteins. Citation: Chaumont A, Voisin C, Deumer G, Haufroid V, Annesi-Maesano I, Roels H, Thijs L, Staessen J, Bernard A. 2013. Associations of urinary cadmium with age and urinary proteins: further evidence of physiological variations unrelated to metal accumulation and toxicity. Environ Health Perspect 121:1047–1053; http://dx.doi.org/10.1289/ehp.1306607 |
| Databáze: | OpenAIRE |
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