Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents
| Autor: | Hiroyuki Osada, Takayuki Teruya, Keisuke Ishida, Siro Simizu, Michal K. Wierzba |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Clinical Biochemistry
Pharmaceutical Science Antineoplastic Agents Biochemistry HeLa Inhibitory Concentration 50 Structure-Activity Relationship chemistry.chemical_compound Cell Movement Cell Line Tumor Drug Discovery Cell Adhesion Humans Neoplasm Invasiveness Molecular Biology Cell Proliferation Dose-Response Relationship Drug biology Cell growth Molecular Mimicry Organic Chemistry Heparan sulfate Adhesion biology.organism_classification In vitro Fibronectins Fibronectin chemistry Cell culture Drug Design biology.protein Molecular Medicine HT1080 Heparitin Sulfate |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 14:2505-2509 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2004.03.009 |
| Popis: | A biological evaluation of the antiadhesive activity of novel heparan sulfate glycosaminoglycans mimetic compounds (KI-compounds) is described. In an adhesion assay, KI-111 [2-(4-fluoro-3-nitrobenzoyl)benzoic acetic anhydride] was found to exert potent inhibitory activities against the adhesion of human fibrosarcoma HT1080 cells and HeLa cells to fibronectin. Cell growth, migration, and invasion of HT1080 cells were also inhibited by KI-111 at almost equal concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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