Methylphenidate administration promotes sociability and reduces aggression in a mouse model of callousness

Autor:	Francesca Zoratto, Simone Macrì, Giovanni Laviola, Francesca Franchi
Rok vydání:	2019
Předmět:	Conduct Disorder Male media_common.quotation_subject Emotions Psychopathy Emotional contagion Empathy Mice 03 medical and health sciences 0302 clinical medicine Dopamine Uptake Inhibitors medicine Animals Attention media_common Pharmacology Mice Inbred BALB C Aggression Methylphenidate Attentional control medicine.disease 030227 psychiatry Disease Models Animal Conduct disorder Trait medicine.symptom Psychology 030217 neurology & neurosurgery Clinical psychology medicine.drug
Zdroj:	Psychopharmacology. 236:2593-2611
ISSN:	1432-2072 0033-3158
DOI:	10.1007/s00213-019-05229-9
Popis:	Deficits in empathy constitute a distinctive feature of several psychopathologies, including conduct disorder (CD). The co-occurrence of callous-unemotional (CU) traits, excess rates of aggression and violation of societal norms confers specific risk for adult psychopathy. To date, the off-label use of methylphenidate (MPH) constitutes the drug treatment of choice. Herein, we tested the therapeutic potential of MPH in a recently devised mouse model recapitulating the core phenotypic abnormalities of CD. Two subgroups of BALB/cJ male mice exhibiting opposite profiles of emotional contagion (i.e. socially transmitted adoption of another’s emotional states) were investigated for reactive aggression, sociability, attention control, anxiety-related behaviours and locomotor activity, in response to MPH administration (0.0, 3.0 or 6.0 mg/kg). Our data indicate that mice selected for excess callousness exhibit phenotypic abnormalities isomorphic to the symptoms of CD: stability of the low emotional contagion trait, increased aggression and reduced sociability. In accordance with our predictions, MPH reduced aggression and increased sociability in callous mice; yet, it failed to restore the low responsiveness to the emotions of a conspecific in pain, isomorphic to CU traits. Although our data support the notion that MPH may contribute to the management of excess aggression in CD patients, additional studies shall identify specific treatments to target the callousness domain. The latter, unaffected by MPH in our experimental model, demands focused consideration whereby it constitutes a specifier associated with a worse prognosis.
Databáze:	OpenAIRE
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