Lipid Raft Alterations in Aged-Associated Neuropathologies
| Autor: | Ana Canerina-Amaro, Mario Díaz, Deiene Rodriguez-Barreto, Noemí Fabelo, Raquel Marin, Fátima Mesa-Herrera, Cecilia Fernández-Echevarría, David Quinto-Alemany |
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| Předmět: |
0301 basic medicine
Cell signaling Aging Disease Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Membrane Microdomains Animals Humans Lipid raft Cell survival Cholesterol Synapsis Neurodegenerative Diseases Raft Sphingolipid Cell biology 030104 developmental biology Neurology chemistry Disease Progression lipids (amino acids peptides and proteins) Neurology (clinical) 030217 neurology & neurosurgery |
| Zdroj: | ResearcherID |
| Popis: | Lipid rafts are membrane microdomains particularly enriched in cholesterol, sphingolipids and saturated fatty acids. These microstructures play a key role in a plethora of mechanisms involved in cell signaling, synapsis, cell-cell communication and cell survival. In the last years, increasing evidence indicate that lipid rafts may be altered in age-related neuropathologies, such as Alzheimer's disease and Parkinson disease even at asymptomatic stages. In particular, important changes in raft lipid composition are observed with the progression of these diseases, then inducing alterations in their physicochemical properties. Furthermore, these phenomena contribute to neuropathological events related to amyloidogenesis, aberrant protein aggregation and toxic cell signalling. In this review, we discuss some relevant data on the age-related molecular changes occurring in lipid rafts since the first stages of these neurodegenerative diseases. Further characterization of specific parameters associated with alterations of these microdomains may provide potential tools of diagnosis and prediction of these neuropathologies. |
| Databáze: | OpenAIRE |
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