Differences in placental capillary shear stress in fetal growth restriction may affect endothelial cell function and vascular network formation
Autor: | Shier Nee Saw, Win Min Tun, Choon Hwai Yap, Joanna L. James, Alys R. Clark |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Cell biology Angiogenesis Science Placenta Cell Neovascularization Physiologic Biology Article Neovascularization Andrology 03 medical and health sciences Fetus 0302 clinical medicine Pregnancy Fetal growth medicine Shear stress Humans Fetal Growth Retardation Multidisciplinary Endothelial Cells Computational biology and bioinformatics Capillaries Endothelial stem cell 030104 developmental biology medicine.anatomical_structure Medicine Gestation Female medicine.symptom Structural biology Shear Strength 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) |
ISSN: | 2045-2322 |
Popis: | Fetal growth restriction (FGR) affects 5–10% of pregnancies, leading to clinically significant fetal morbidity and mortality. FGR placentae frequently exhibit poor vascular branching, but the mechanisms driving this are poorly understood. We hypothesize that vascular structural malformation at the organ level alters microvascular shear stress, impairing angiogenesis. A computational model of placental vasculature predicted elevated placental micro-vascular shear stress in FGR placentae (0.2 Pa in severe FGR vs 0.05 Pa in normal placentae). Endothelial cells cultured under predicted FGR shear stresses migrated significantly slower and with greater persistence than in shear stresses predicted in normal placentae. These cell behaviors suggest a dominance of vessel elongation over branching. Taken together, these results suggest (1) poor vascular development increases vessel shear stress, (2) increased shear stress induces cell behaviors that impair capillary branching angiogenesis, and (3) impaired branching angiogenesis continues to drive elevated shear stress, jeopardizing further vascular formation. Inadequate vascular branching early in gestation could kick off this cyclic loop and continue to negatively impact placental angiogenesis throughout gestation. |
Databáze: | OpenAIRE |
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