Squamous cell carcinoma antigen in the diagnosis and treatment follow-up of oral and facial squamous cell carcinoma
| Autor: | Thomas Meyer, Klaus Barthel, Wolfgang Fischbach |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Radioimmunoassay Squamous cell carcinoma Antigen Gastroenterology Elevated serum Antigen Antigens Neoplasm Internal medicine Early prediction Biomarkers Tumor Medicine Humans Basal cell Serpins business.industry Serum concentration stomatognathic diseases Oncology Carcinoma Squamous Cell Female Mouth Neoplasms Facial Neoplasms business Treatment follow up Follow-Up Studies |
| Zdroj: | Cancer. 65(6) |
| ISSN: | 0008-543X |
| Popis: | The squamous cell carcinoma (SCC) antigen was determined by radioimmunoassay in the serum of 40 untreated patients with SCC of the oromaxillofacial region. The mean (+/- SEM) serum concentration for these patients (3.8 +/- 0.8 ng/ml) was significantly higher than that of 52 disease-free patients coming to routine postoperative care (1.2 +/- 0.1 ng/ml) and of 74 healthy controls (1.1 +/- 0.07 ng/ml). Using a arbitrary limit of 2.2 ng/ml, pathologic serum levels of SCC were observed in 15 (38%) of 40 untreated patients, whereas only four (7.7%) of 52 tumor-free patients revealed an elevated serum SCC. Serial measurements of SCC were pretherapeutically available in 28 patients as well as during individual therapy and further follow-up. All but one of these patients had a normal serum SCC postoperatively. The authors' results demonstrate that the clinical value of SCC lies mainly in monitoring the course of the disease. Careful follow-up studies should be undertaken to determine whether serial determination of SCC is promising in early prediction of tumor reoccurrence. |
| Databáze: | OpenAIRE |
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