CD4 CELL COUNT CRITERIA TO DETERMINE WHEN TO INITIATE ANTIRETROVIRAL THERAPY IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED CHILDREN
| Autor: | Wicharn Luesomboon, Stephen J. Kerr, Jintanat Ananworanich, Tulathip Suwanlerk, Sasiwimol Ubolyam, Pope Kosalaraksa, Chaiwat Ngampiyaskul, Thanyawee Puthanakit, Kiat Ruxrungtham, Suparat Kanjanavanit, Vonthanak Saphonn, Rawiwan Hansudewechakul, Nicole Ngo-Giang-Huong, Mom Chandara, Jurai Wongsawat |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Microbiology (medical) Pediatrics medicine.medical_specialty Anti-HIV Agents Population HIV Infections Sensitivity and Specificity Article Pharmacotherapy Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Immunopathology Humans Medicine Child education Sida Randomized Controlled Trials as Topic education.field_of_study biology business.industry Guideline Thailand medicine.disease biology.organism_classification CD4 Lymphocyte Count Infectious Diseases Child Preschool Practice Guidelines as Topic Pediatrics Perinatology and Child Health Immunology Lentivirus Female Viral disease Cambodia business |
| Zdroj: | Pediatric Infectious Disease Journal. 29:966-968 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/inf.0b013e3181e0554c |
| Popis: | We evaluated the validity of CD4 count against CD4% criteria of 2008 World Health Organization guideline for initiating antiretroviral therapy using the data of 446 human immunodeficiency virus-infected Asian children aged 1 to 12 years who were screened to the Pediatric Randomized of Early versus Deferred Initiation in Cambodia and Thailand study. The overall sensitivity and specificity were 34% and 98%, respectively. Using the current CD4 count criteria would globally result in 66% missed opportunity to initiate treatment in a timely fashion. Raising CD4 count thresholds should be considered to increase its sensitivity and reduce missed opportunity. |
| Databáze: | OpenAIRE |
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