Tonsil lymphoma presenting as tonsillitis after bone marrow transplantation
| Autor: | Michael H. Weiss, Seth A. Yellin, Dennis H. Kraus, Esperanza B. Papadopoulos |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Herpesvirus 4 Human medicine.medical_specialty medicine.medical_treatment Tonsillar Neoplasms Tonsillitis Lymph node biopsy 03 medical and health sciences 0302 clinical medicine Cervical lymphadenopathy Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Immune Tolerance medicine Humans 030223 otorhinolaryngology Bone Marrow Transplantation medicine.diagnostic_test business.industry Neoplasms Second Primary Immunosuppression Middle Aged medicine.disease Pharyngitis Lymphoma Surgery Tonsillectomy Leukemia Myeloid Acute Tumor Virus Infections Leukemia Otorhinolaryngology Leukemia Myeloid 030220 oncology & carcinogenesis Female Lymphoma Large B-Cell Diffuse medicine.symptom business |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 112:544-548 |
| ISSN: | 1097-6817 0194-5998 |
| DOI: | 10.1177/019459989511200407 |
| Popis: | Bone marrow transplantation for the treatment of leukemia is increasingly successful in rendering patients disease free. However, it has become evident that the associated severe immunosuppression predisposes this population to an increased risk for other neoplastic disorders. We report on six patients in whom non-Hodgkin's lymphoma of the tonsillar region developed within 5 months after T-cell – depleted bone marrow transplantation for the treatment of leukemia at Memorial Sloan-Kettering Cancer Center from October 1990 to October 1992. These patients initially had what appeared to be infectious exudative pharyngitis/tonsillitis; however, they did not improve with medical therapy. Because of the persistence of pharyngitis/tonsillitis in association with cervical lymphadenopathy and odynophagia, the patients underwent definitive biopsy in the form of tonsillectomy, cervical lymph node biopsy, or both. Histopathologic review revealed non-Hodgkin's lymphoma. An association with Epstein-Barr virus has been noted in five of these patients. This article is aimed at alerting the clinician to consider the diagnosis of lymphoma in a patient with persistent pharyngitis/tonsillitis despite adequate medical therapy after bone marrow transplantation. (OTOLARYNGOL HEAD NECK SURG 1995;112:544-8.) |
| Databáze: | OpenAIRE |
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