Time-restricted feeding delays the emergence of the age-associated, neoplastic-prone tissue landscape
| Autor: | Ezio Laconi, Mariangela Serra, Fabio Marongiu, Mônica Campos Serra, Maria Giuseppina Pisu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Senescence Aging medicine.medical_specialty medicine.medical_treatment Hippocampal formation Biology medicine.disease_cause Persistence (computer science) Eating Neoplasms Internal medicine Tumor Microenvironment medicine Animals Cellular Senescence Growth factor Liver cell Cancer Fasting Cell Biology tissue microenvironment medicine.disease Phenotype Rats Disease Models Animal Endocrinology Liver Hepatocytes time restricted feeding Carcinogenesis carcinogenesis Research Paper |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| DOI: | 10.18632/aging.102021 |
| Popis: | Aging increases the risk of cancer partly through alterations in the tissue microenvironment. Time-restricted feeding (TRF) is being proposed as an effective strategy to delay biological aging. In the present studies, we assessed the effect of long-term exposure to TRF on the emergence of the age-associated, neoplastic-prone tissue landscape. Animals were exposed to either ad libitum feeding (ALF) or TRF for 18 months and then transplanted with hepatocytes isolated from pre-neoplastic nodules. Both groups were continued ALF and the growth of transplanted cells was evaluated 3 months later. A significant decrease in frequency of larger size clusters of pre-neoplastic hepatocytes was seen in TRF-exposed group compared to controls. Furthermore, TRF modified several parameters related to both liver and systemic aging towards the persistence of a younger phenotype, including a decrease in liver cell senescence, diminished fat accumulation and up-regulation of SIRT1 in the liver, down-regulation of plasma IGF-1, decreased levels of plasma lipoproteins and up-regulation of hippocampal brain-derived growth factor (BDNF).These results indicate that TRF was able to delay the onset of the neoplastic-prone tissue landscape typical of aging. To our knowledge, this is the first investigation to describe a direct beneficial effect of TRF on early phases of carcinogenesis. |
| Databáze: | OpenAIRE |
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