Determination of genotoxic effects in hemodialysis patients with chronic kidney disease and the role of diabetes mellitus and other biochemical parameters
| Autor: | Serpil Muge Deger, Fatma Ünal, Sevcan Mamur, Deniz Yüzbaşıoğlu, Kadriye Altok |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Health Toxicology and Mutagenesis medicine.medical_treatment Sister chromatid exchange Comorbidity 010501 environmental sciences 01 natural sciences Gastroenterology Body Mass Index 03 medical and health sciences Young Adult Renal Dialysis Internal medicine Diabetes mellitus Genetics medicine Mitotic Index Humans Diabetic Nephropathies Renal Insufficiency Chronic 0105 earth and related environmental sciences Aged Aged 80 and over Chromosome Aberrations Micronucleus Tests biology business.industry Mutagenicity Tests medicine.disease Ferritin 030104 developmental biology Ferritins Hypertension biology.protein Etiology Regression Analysis Female Hemodialysis business Micronucleus Body mass index Sister Chromatid Exchange Kidney disease |
| Popis: | Chronic kidney disease (CKD) is a common health problem. The primary etiology of CKD is diabetes mellitus (DM). The aim of our study is to determine the possible role of DM and also effects of other factors such as hypertension, duration of hemodialysis (HD), age, sex, body mass index (BMI), and levels of hemoglobin (HB), intact parathormone (iPTH), and ferritin on genetic alterations in maintenance HD patients using chromosomal aberrations (CAs), sister chromatid exchanges (SCEs), and micronucleus (MN) tests. According to the results, the frequency of CAs (p = 0.001), SCEs (p < 0.001) and MN (p < 0.001) statistically increased in HD patients compared to controls. However, there was no significant effect of diabetes as well as other factors on CA, SCE (except at factor of age), and MN in HD patients compared to controls. The mitotic (MI), replication (RI) and nuclear division indices (NDI) significantly decreased in HD patients compared to controls (p < 0.001). In addition, RI (p < 0.001) and NDI (p = 0.047) were significantly decreased in diabetic HD patients than the nondiabetic HD patients. There was no relation between the frequency of CA, SCE and MN and duration of HD treatment with correlation analysis. According to univariate regression analyses, only having CKD was significantly associated with the values of CA, SCE and MN. However, in multivariate analyses, only having CKD remained as significantly associated with CA, SCE and MN values. Consequently, the clastogenic and mutagenic effects increased in HD patients compared to controls; unlike DM in which cell proliferation decreased. |
| Databáze: | OpenAIRE |
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