A Proposed Consensus Steroid-Binding Sequence—a Reply
Autor: | Jacqueline A. Lees, Stephen E. Fawell, Malcolm G. Parker |
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Rok vydání: | 1989 |
Předmět: |
Receptors
Steroid medicine.medical_treatment Molecular Sequence Data Mutant Wild type General Medicine Biology DNA-binding protein Steroid Steroid hormone Endocrinology Biochemistry Mutation Consensus sequence medicine Animals Amino Acid Sequence Rabbits Chromosome Deletion Binding site Carrier Proteins Receptor Molecular Biology |
Zdroj: | Molecular Endocrinology. 3:1002-1005 |
ISSN: | 1944-9917 0888-8809 |
Popis: | A consensus sequence has been proposed as necessary for steroid binding on the basis of sequence homology in steroidogenic enzymes, steroid binding proteins and steroid receptors. We have mapped the limit of sequences important for steroid binding in the mouse estrogen receptor using Scatchard analysis of deletion mutants. Since a mutant lacking the entire proposed consensus is still able to bind estradiol with essentially wild type affinity, the functional significance of this motif is unclear. |
Databáze: | OpenAIRE |
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