Synergistic effect of cadmium chloride and acetaldehyde on cytotoxicity and its prevention by quercetin and glycyrrhizin
| Autor: | Chao-Chin Hu, Pel-Hu Liao, Wen-Kang Chen, Wei-Che Yu, Yean-Jang Lee |
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| Rok vydání: | 2001 |
| Předmět: |
Hypoxanthine Phosphoribosyltransferase
Antioxidant Cell Survival Health Toxicology and Mutagenesis medicine.medical_treatment chemistry.chemical_element Acetaldehyde Cadmium chloride medicine.disease_cause Rhodamine 123 Cell Line Membrane Potentials chemistry.chemical_compound Cricetulus Cadmium Chloride Cricetinae Genetics medicine Animals Glycyrrhizin Cadmium Dose-Response Relationship Drug Lipid peroxide Antimutagenic Agents Drug Synergism Intracellular Membranes Glycyrrhizic Acid Mitochondria chemistry Biochemistry Quercetin Lipid Peroxidation Genotoxicity Mutagens |
| Zdroj: | Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 496:117-127 |
| ISSN: | 1383-5718 |
| DOI: | 10.1016/s1383-5718(01)00214-5 |
| Popis: | Cadmium chloride at concentrations of 10-50mM and acetaldehyde (AA) at 1-5mM showed synergistic toxic effects on V79 cells in vitro. Furthermore, synergistic effects of these chemicals were also observed in mutagenicities of the Hprt gene within certain dose ranges (cadmium chloride 5-10mM, and AA 1-2.5mM). Moreover, lipid peroxide formation, malondialdehyde (MDA) formation, detected by 2-thiobarbituric acid (TBA) reaction and the mitochondrial membrane potentials detected by rhodamine 123 uptake were significantly increased with the combined effect of cadmium and AA in V79. Thus, the cytotoxicity and genotoxicity displayed by combination of these chemicals can be considered to be associated with oxidative stress. Further, these effects were efficiently reduced by quercetin and less efficiently with glycyrrhizin. |
| Databáze: | OpenAIRE |
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