Effect of hematopoietic growth factors on MR images of bone marrow in children undergoing chemotherapy
| Autor: | Barry D. Fletcher, J E Wall, S L Hanna |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Pathology Adolescent medicine.medical_treatment Bone Neoplasms Soft Tissue Neoplasms Granulocyte Muscular Diseases Bone Marrow Granulocyte Colony-Stimulating Factor medicine Humans Combined Modality Therapy Radiology Nuclear Medicine and imaging Child Pelvis Pelvic Neoplasms Osteosarcoma Chemotherapy medicine.diagnostic_test business.industry Femoral Neoplasms Growth factor Granulocyte-Macrophage Colony-Stimulating Factor Magnetic resonance imaging Magnetic Resonance Imaging Haematopoiesis medicine.anatomical_structure Child Preschool Female Bone marrow Radiology business |
| Zdroj: | Radiology. 189:745-751 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.189.3.7694312 |
| Popis: | To evaluate the effects of hematopoietic growth factors on magnetic resonance (MR) image signal intensity (SI) of bone marrow in children undergoing neoadjuvant chemotherapy for musculoskeletal malignancies.Blinded evaluations were performed of T1-weighted and short inversion time inversion recovery images of the pelvis and/or lower extremities of 15 patients undergoing chemotherapy, with or without granulocyte or granulocyte-macrophage colony-stimulating factor.Four of the 11 patients who received growth factors initially had hematopoietic marrow SI that did not change during therapy. All seven with initially fatty marrow had SI changes consistent with reconversion to hematopoietic marrow that coincided temporally with increases in absolute neutrophil counts from minimums of 0-2,580/mm3 to maximums of 10,858-45,880/mm3. The four patients who did not receive growth factors had no MR imaging changes in initially hematopoietic (n = 1) or fatty (n = 3) marrow.Hematopoietic activity induced by growth factors can produce changes in bone marrow SI that may simulate bone marrow involvement by musculoskeletal tumors. |
| Databáze: | OpenAIRE |
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