Affective Behavior Shows Sex Differences in Mid-adulthood Rats Following Postnatal Immune Stimulation
| Autor: | Duyilemi Chris Ajonijebu, A. El Hessni, A. Mesfioui, Ali Ouichou, Inssaf Berkiks, R. Nakache |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Lipopolysaccharides Male medicine.medical_specialty Lipopolysaccharide Prefrontal Cortex Anxiety Nitric Oxide Hippocampus Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Sex Factors Internal medicine Malondialdehyde medicine Animals Rats Wistar Prefrontal cortex Pathological Neuroinflammation Inflammation Behavior Animal business.industry Depression Tumor Necrosis Factor-alpha General Neuroscience Immunosenescence Rats 030104 developmental biology Endocrinology chemistry Animals Newborn Tumor necrosis factor alpha Female Microglia business 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience. 421 |
| ISSN: | 1873-7544 |
| Popis: | Mid-adulthood represents the critical window period usually associated with the development of age-related diseases. Despite several attempts to delineate the pathological mechanisms underlying postnatal immune challenge and altered brain functions, the role of sex-dependent changes in affective behaviors of middle-aged animals requires more attention. In this study, we sought to investigate behavioral and molecular response patterns at mid-adulthood linked to early-life immune activation. Using affective behavioral test batteries, we showed that lipopolysaccharide (LPS)-induced postnatal immune challenge caused anxiety-like behaviors in both male and female Wistar rats at mid-adulthood, whereas only female rats exhibited depression-like behaviors. Our data further demonstrated a significant increase in microglial complexity and increased levels of tumor necrosis factor (TNFα), nitric oxide (NOx), and lipid peroxidation in the prefrontal cortex of female rats compared to their male counterparts and phosphate-buffered saline (PBS) littermate controls. With these results, we established significant interaction between sex differences and LPS-induced alterations in behavior and associated oxidative and immunohistochemical changes. These findings may provide an insight to better understand the neuroimmunological mechanisms of sex-dependent brain pathological manifestations occurring at mid-adulthood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect