Acute bile nephropathy secondary to anabolic steroids
| Autor: | Mohamed A. ElTigani, Rola S Rabah, Ahmed M. Alkhunaizi, Samih H. Nasr |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Weight Lifting Bilirubin Biopsy 030232 urology & nephrology Gastroenterology Anabolic Agents Nephropathy Bile Acids and Salts Oxandrolone 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Medicine Bile Humans Clenbuterol Testosterone Creatinine Kidney urogenital system business.industry Acute kidney injury General Medicine Jaundice Acute Kidney Injury Adrenergic beta-Agonists medicine.disease Jaundice Obstructive medicine.anatomical_structure Kidney Tubules chemistry Nephrology Androgens Triiodothyronine 030211 gastroenterology & hepatology medicine.symptom business Stanozolol medicine.drug |
| Zdroj: | Clinical nephrology. 85(2) |
| ISSN: | 0301-0430 |
| Popis: | Renal dysfunction in cholestatic liver disease is multifactorial. Acute kidney injury may develop secondary to renal vasoconstriction in the setting of peripheral vasodilation and relative hypovolemia, tubular obstruction by bile casts, and direct tubular toxicity from bile. Anabolic steroids are frequently used by athletes to boost endurance and increase muscle mass. These agents are a recently recognized cause of hepatotoxicity and jaundice and may lead to acute kidney injury. To increase awareness about this growing problem and to characterize the pathology of acute kidney injury in this setting, we report on a young male who developed acute kidney injury in the setting of severe cholestatic jaundice related to ingestion of anabolic steroids used for bodybuilding. Kidney biopsy showed bile casts within distal tubular lumina, filamentous bile inclusions within tubular cells, and signs of acute tubular injury. This report supports the recently re-emerged concept of bile nephropathy cholemic nephrosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|