Hemorheologic and coagulative pattern in hypercholesterolemic subjects treated with lipid-lowering drugs
| Autor: | Mario Bo, Pernigotti L, Fabrizio Fabris, F. Bonino, Mario Molaschi, M. Neirotti, M. Gottero |
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| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Simvastatin medicine.medical_treatment Hypercholesterolemia 030204 cardiovascular system & hematology Fibrinogen 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Lovastatin Blood Coagulation Triglycerides Aged Chemotherapy Hemostasis Bezafibrate business.industry Anticholesteremic Agents Antithrombin Biological activity Middle Aged Blood Coagulation Factors Endocrinology Coagulative necrosis Cholesterol Female Lipid lowering Cardiology and Cardiovascular Medicine business medicine.drug |
| Popis: | The effects on the coagulative and rheologic pattern of two lipid-lowering drugs, bezafibrate and simvastatin, were studied in 36 hypercholesterolemic subjects. Patients were randomly divided into two groups (18 subjects each) and received bezafibrate R 400 mg/day or simvatatin 10-40 mg/day over a twelve week period. Besides a decrease in plasma fibrinogen and fibrinopeptide A (p less than 0.001 both), bezafibrate induced a reduction of factor VIIc and VIIIc activity (p less than 0.001 both), while antithrombin 3 activity was increased (p less than 0.001) and the hemorheologic pattern was greatly improved (p less than 0.001). Simvastatin caused a slight decrease in factor VIIIc activity and a moderate reduction of beta-thromboglobulin. The efficacy of bezafibrate in reducing the activation of the coagulative cascade and improving the hemorheologic pattern has been confirmed; the peculiar triglycerides- and fibrinogen-lowering effect of the drug, not observed with simvastatin, could be responsible for these modifications. |
| Databáze: | OpenAIRE |
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