Identification of therapeutic targets for inflammation in sickle cell disease (SCD) among Indian patients using gene expression data analysis
| Autor: | Pradeep Kumar Patra, Hrishikesh Mishra, Ipsita Das, P. K. Khodiar |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Blood transfusion business.industry medicine.medical_treatment Cell Inflammation General Medicine Disease medicine.disease Pathophysiology medicine.anatomical_structure Hemoglobinopathy hemic and lymphatic diseases Immunology medicine Platelet medicine.symptom business Vaso-occlusive crisis |
| Zdroj: | Bioinformation. 14:408-413 |
| ISSN: | 0973-2063 0973-8894 |
| DOI: | 10.6026/97320630014408 |
| Popis: | Sickle cell disease (SCD) is life-threatening hemoglobinopathy prevalent in India, Sub-Saharan Africa and Middle East. Inflammation plays a pivotal role in disease process and involves intricate interaction among leukocytes, platelets, sickle erythrocytes and vascular endothelium. Available disease modifying therapies are hydroxyl-urea and blood transfusion. Therefore, it is of interest to develop improved pharmacological agents for SCD. We report up-regulated genes in steady state and vaso-occlusive crisis using analysis of gene expression data obtained by microarray experiment for SCD as potential targets. The association of these targets with inflammation in pathway analysis is also documented. |
| Databáze: | OpenAIRE |
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