Tumor del estroma gastrointestinal (GIST) en una paciente con neurofibromatosis tipo 1

Autor:	Carlos Barría, Karina S. Cruces, Christian S Wilson, Mario A. Contreras, Marcelo A. Beltrán
Jazyk:	Spanish; Castilian
Rok vydání:	2009
Předmět:	Pathology medicine.medical_specialty Stromal cell Neurofibromatosis 1 GiST business.industry CD34 General Medicine Anastomosis medicine.disease Asymptomatic Protein kinase inhitors Medicine Gastrointestinal stromal tumors Desmin medicine.symptom Stromal tumor Neurofibromatosis business
Zdroj:	Revista médica de Chile v.137 n.9 2009 SciELO Chile CONICYT Chile instacron:CONICYT
Popis:	Neurofibromatosis Type 1 (NF1) is an autosomic dominant condition affecting the central nervous systema and presenting a disposition towards development of gastrointestinal stromal tumors (GIST). We report a 38year-old female patient with neurofibromatosis type 1 that required emergency surgery due to a perforated GIST originating in the fourth duodenal portion. The GIST, and the fourth duodenal portion, were excised and a primary duodenum-jejunal anastomosis was performed. The pathological study showed a partially necrotic solid-cystic tumor with 1 to 2 mitoses per 50-high-power fields. The cells stained positively to CD 117, CD34 and Desmin, and were negative to S-100, Vimentin, and Smooth Muscle a-Actin. The patient is currently asymptomatic and under follow-up during the last 11 months after surgery (Rev Méd Chile 2009; 137:1197-200).
Databáze:	OpenAIRE
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