Prognostic Validation of the NINDS Common Data Elements for the Radiologic Reporting of Acute Traumatic Brain Injuries: A CENTER-TBI Study
| Autor: | R.H.M.A. Bartels, Paul M. Parizel, Thomas Van Essen, Daniel Kondziella, Juan Sahuquillo, Oliver Sakowitz, Steven Laureys, Angelos Kolias, Ana M Castaño-Leon, Matti Pirinen, Thijs Vande Vyvere, Morten Blaabjerg, Giuseppe Citerio, Rahul Raj, Jussi Posti, Renán Sánchez-Porras, Andreea Rădoi, D. James Cooper, Sandra Rossi, Pedro Gomez, Virginia Newcombe, William Stewart, Jonathan Coles, Frederick Zeiler, Aarno Palotie, Arminas Ragauskas |
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| Přispěvatelé: | Vande Vyvere, Thij, De La Rosa, Ezequiel, Wilms, Guido, Nieboer, Daan, Steyerberg, Ewout, Maas, Andrew I R, Verheyden, Jan, van den Hauwe, Luc, Parizel, Paul M (CENTER-TBI Participants and Investigators), Beretta, Luigi, Molecular Neuroscience and Ageing Research (MOLAR), Vande Vyvere, T, De La Rosa, E, Wilms, G, Nieboer, D, Steyerberg, E, Maas, A, Verheyden, J, Van Den Hauwe, L, Parizel, P, Citerio, G, CTR-TBI Participants Investigators, Public Health |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Research Report SELECTION medicine.medical_specialty Neurology Adolescent Databases Factual Traumatic brain injury INTRACEREBRAL HEMORRHAGE Poison control Logistic regression Young Adult Common Data Element Internal medicine TOMOGRAPHY Injury prevention Brain Injuries Traumatic medicine Humans National Institute of Neurological Disorders and Stroke (U.S.) Longitudinal Studies structured reporting Child Stroke Aged Intracerebral hemorrhage Aged 80 and over Common Data Elements business.industry Glasgow Outcome Scale traumatic brain injury Infant Newborn Infant Reproducibility of Results computed tomography Middle Aged medicine.disease Prognosis United States Child Preschool SIMULATION Female Neurology (clinical) Human medicine business Tomography X-Ray Computed |
| Zdroj: | Journal of Neurotrauma, 37(11), 1269-1282. MARY ANN LIEBERT, INC Journal of neurotrauma Journal of Neurotrauma, 37(11), 1269-1282. Mary Ann Liebert Inc. |
| ISSN: | 0897-7151 1557-9042 |
| Popis: | The aim of this study is to investigate the prognostic value of using the National Institute of Neurological Disorders and Stroke (NINDS) standardized imaging-based pathoanatomic descriptors for the evaluation and reporting of acute traumatic brain injury (TBI) lesions. For a total of 3392 patients (2244 males and 1148 females, median age = 51 years) enrolled in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, we extracted 96 Common Data Elements (CDEs) from the structured reports, spanning all three levels of pathoanatomic information (i.e., 20 "basic," 60 "descriptive," and 16 "advanced" CDE variables per patient). Six-month clinical outcome scores were dichotomized into favorable (Glasgow Outcome Scale Extended [GOS-E] = 5-8) versus unfavorable (GOS-E = 1-4). Regularized logistic regression models were constructed and compared using the optimism-corrected area under the curve (AUC). An abnormality was reported for the majority of patients (64.51%). In 79.11% of those patients, there was at least one coexisting pathoanatomic lesion or associated finding. An increase in lesion severity, laterality, and volume was associated with more unfavorable outcomes. Compared with the full set of pathoanatomic descriptors (i.e., all three categories of information), reporting "basic" CDE information provides at least equal discrimination between patients with favorable versus unfavorable outcome (AUC = 0.8121 vs. 0.8155, respectively). Addition of a selected subset of "descriptive" detail to the basic CDEs could improve outcome prediction (AUC = 0.8248). Addition of "advanced" or "emerging/exploratory" information had minimal prognostic value. Our results show that the NINDS standardized-imaging based pathoanatomic descriptors can be used in large-scale studies and provide important insights into acute TBI lesion patterns. When used in clinical predictive models, they can provide excellent discrimination between patients with favorable and unfavorable 6-month outcomes. If further validated, our findings could support the development of structured and itemized templates in routine clinical radiology. |
| Databáze: | OpenAIRE |
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