Potential molecular mechanisms of zinc- and copper-mediated antiviral activity on COVID-19

Autor: Rajendra Prasad, Isha Rani, Mini Bhatnagar, Parul Goel, Sunita Manhas, Anmol Goyal, Amit Pal
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Antioxidant
Coronavirus Disease 2019 (COVID-19)
Bcl-2
B-cell lymphoma 2
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Anti-Inflammatory Agents
IFN
interferons
Pharmacology
Antioxidants
0302 clinical medicine
Endocrinology
NK cells
natural killer cells
Copper (Cu)
Cu
copper
chemistry.chemical_classification
Nutrition and Dietetics
ATP7A
copper-ATPase
ZIP
Zrt-/Irt-like protein
MTF-1
metal-responsive transcription factor-1
Nrf 2
nuclear erythroid factor 2
Gastrointestinal system
Zn
zinc
Zinc
Zinc (Zn)
Th
T helper cell
Adjuvant
NF-κB
nuclear factor-κB
030209 endocrinology & metabolism
ATOX1
human antioxidant protein 1
Antiviral Agents
Article
03 medical and health sciences
ACE2
angiotensin-converting enzyme-2
Immune system
ROS
reactive oxygen species
Viral entry
SOD
superoxide dismutase
RdRP
RNA dependent RNA polymerase
medicine
Adjuvant therapy
Humans
CTR1
copper transporter protein
ZnT
zinc transporter
CCS
copper chaperone for superoxide dismutase
ARDS
acute respiratory distress syndrome
Reactive oxygen species
Trace elements
030109 nutrition & dietetics
Zo-1
zonula occludens-1
SARS-CoV-2
business.industry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Bax
bcl-2-like protein 4
Autophagy
MT
metallothionein
COVID-19 Drug Treatment
IL
interleukin
Clinical trial
chemistry
MRE
metal-responsive element
SIRT1
NAD-dependent deacetylase sirtuin-1
business
Copper
SARS-CoV-2
severe acute respiratory syndrome coronavirus-2
Zdroj: Nutrition Research (New York, N.y.)
ISSN: 1879-0739
0271-5317
Popis: Novel coronavirus disease 2019 (COVID-19) has spread across the globe; and surprisingly, no potentially protective or therapeutic antiviral molecules are available to treat severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, zinc (Zn) and copper (Cu) have been shown to exert protective effects due to their antioxidant, anti-inflammatory, and antiviral properties. Therefore, it is hypothesized that supplementation with Zn and Cu alone or as an adjuvant may be beneficial with promising efficacy and a favorable safety profile to mitigate symptoms, as well as halt progression of the severe form of SARS-CoV-2 infection. The objective of this review is to discuss the proposed underlying molecular mechanisms and their implications for combating SARS-CoV-2 infection in response to Zn and Cu administration. Several clinical trials have also included the use of Zn as an adjuvant therapy with dietary regimens/antiviral drugs against COVID-19 infection. Overall, this review summarizes that nutritional intervention with Zn and Cu may offer an alternative treatment strategy by eliciting their virucidal effects through several fundamental molecular cascades, such as, modulation of immune responses, redox signaling, autophagy, and obstruction of viral entry and genome replication during SARS-CoV-2 infection.
Databáze: OpenAIRE
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