Involvement of melanocortin receptor accessory proteins (MRAPs) in the function of melanocortin receptors
| Autor: | M. Eley, Esther Leal, Sara Puchol, José Miguel Cerdá-Reverter, Begoña Fernández-Durán, Raúl Cortés, Raúl Guillot, Elisa Sánchez, Maria Josep Agulleiro |
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| Rok vydání: | 2013 |
| Předmět: |
endocrine system
medicine.medical_specialty Biology Endocrinology Adrenocorticotropic Hormone Melanocortin receptor Internal medicine medicine Animals Humans Inverse agonist ACTH receptor Receptor Adrenal gland Receptors Melanocortin digestive oral and skin physiology Membrane Proteins Melanocortin 3 receptor medicine.anatomical_structure Animal Science and Zoology Melanocortin Receptor Melanocortin Type 1 Receptor Melanocortin Type 2 hormones hormone substitutes and hormone antagonists Protein Binding Hormone |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0016-6480 2010-2224 |
| Popis: | The melanocortin system integrates different agonists, competitive or inverse agonists, and receptors. Recent investigations have also discovered a specific system of melanocortin receptor accessory proteins (MRAPs) that are involved in the regulation of the functional expression of these receptors. MRAP1 mutations are responsible for type 2 familial glucocorticoid deficiency (FGD2), a rare autosomal disorder characterized by high plasma adrenocorticotropin hormone (ACTH) levels but severe cortisol deficiency. ACTH binds melanocortin 2 receptor (MC2R), a G protein-coupled receptor, in the adrenal gland to promote corticosteroid synthesis. In the absence of MRAP1, MC2R cannot translocate from the endoplasmic reticulum to the plasma membrane and ACTH-induced signaling is extinguished. A second MRAP protein, called MRAP2, also modulates MC2R activity. MRAPs also interact with the other melanocortin receptors, adjusting their pharmacological properties. In this paper, we briefly review the MRAP system and its interaction with melanocortin receptors. © 2013 Elsevier Inc. Grants AGL2010-22247-C03-01 and CSD 2007-00002 from Spanish Science and Education Ministry (MEC) to JMC-R. Additional funding was obtained from the >Generalitat Valenciana> (research grant PROMETEO 2010/006). MJA and RC are recipient of a >Juan de la Cierva> research contract and FPI fellowship, respectively, from MINECO. |
| Databáze: | OpenAIRE |
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