The prevalence of hepatitis B virus and hepatitis C virus infection among patients with chronic liver disease in South India
| Autor: | Shanmugam Saravanan, Kailapuri G. Murugavel, Esaki M. Shankar, Suniti Solomon, Subhadra Nandakumar, Sadras Panchatcharam Thyagarajan, Vijayakumar Velu, Nagalingeswaran Kumarasamy, Pachamuthu Balakrishnan, Sunil S. Solomon |
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| Jazyk: | angličtina |
| Předmět: |
Liver Cirrhosis
Male Microbiology (medical) Hepatitis B virus Hepacivirus Hepatitis C virus India medicine.disease_cause Chronic liver disease Cohort Studies Liver disease Hepatitis B Chronic Orthohepadnavirus Prevalence Humans Medicine Genotype 1b biology business.industry virus diseases General Medicine Hepatitis C Chronic Middle Aged biology.organism_classification medicine.disease Virology digestive system diseases Infectious Diseases Hepadnaviridae Hepatocellular carcinoma Female business |
| Zdroj: | International Journal of Infectious Diseases. (5):513-518 |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2008.02.006 |
| Popis: | SummaryObjectiveDetermining the identity of hepatitis C virus (HCV) genotypes in liver disease has key implications for ascertaining the duration of antiviral therapy and disease prognosis. We investigated the presence of various genotypes of HCV among 69 chronic liver diseased (CLD) patients with chronic HCV infection.MethodsSixty-nine consecutive subjects with underlying chronic hepatitis (n=28), cirrhosis (n=35), and hepatocellular carcinoma (n=6), diagnosed by clinical, biochemical, and histological means, were studied. Hepatitis B virus (HBV) and HCV diagnostic markers were used. HCV-RNA was extracted from sera of HCV-infected subjects and subsequently the HCV genotypes were determined using a commercial line probe assay (Inno-LiPA HCV II).ResultsOf the 69 CLD cases screened for possible markers of HBV and HCV infection, 39 (57%) were positive for HBV and 30 (43%) were HCV infected. The overall HCV-RNA positivity was 77% (23/30). Of these, the majority were genotype 1b (13/23, 57%), followed by 1a (6/23, 26%), mixed genotypes 3 and 4(3/23, 13%), and mixed pattern of 1a, 1b, and 4 (1/23, 4.3%). The genotype 1b infected subjects demonstrated significantly elevated transaminase (ALT) levels (p |
| Databáze: | OpenAIRE |
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