A Computational Study on Temperature Variations in MRgFUS Treatments Using PRF Thermometry Techniques and Optical Probes
| Autor: | Giorgio Ivan Russo, Fabrizio Vicari, Carmelo Militello, Giovanni Borasi, Luca Agnello, Leonardo Rundo, Salvatore Vitabile |
|---|---|
| Přispěvatelé: | Militello, Carmelo [0000-0003-2249-9538], Rundo, Leonardo [0000-0003-3341-5483], Vitabile, Salvatore [0000-0002-2673-8551], Russo, Giorgio [0000-0003-1493-1087], Apollo - University of Cambridge Repository, Militello C., Rundo L., Vicari F., Agnello L., Borasi G., Vitabile S., Russo G. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Optical fiber
Materials science Interferometric optical fibers MRgFUS Proton resonance frequency shift RBF neural networks Referenceless thermometry Temperature variations lcsh:Computer applications to medicine. Medical informatics Imaging phantom lcsh:QA75.5-76.95 Article 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences interferometric optical fibers 0302 clinical medicine law Medical imaging Radiology Nuclear Medicine and imaging lcsh:Photography Electrical and Electronic Engineering Referenceless ther-mometry Proton resonance frequency temperature variations business.industry MRgFUS Ultrasound proton resonance frequency shift Focused ultrasound surgery lcsh:TR1-1050 Computer Graphics and Computer-Aided Design RBF neural networks Clinical Practice Interferometry referenceless thermometry lcsh:R858-859.7 Computer Vision and Pattern Recognition lcsh:Electronic computers. Computer science business 030217 neurology & neurosurgery Interferometric optical fibers Proton resonance frequency shift Temperature variations Biomedical engineering |
| Zdroj: | Journal of Imaging Journal of Imaging, Vol 7, Iss 63, p 63 (2021) JOURNAL OF IMAGING 7 (2021). doi:10.3390/jimaging7040063 info:cnr-pdr/source/autori:Militello, Carmelo; Rundo, Leonardo; Vicari, Fabrizio; Agnello, Luca; Borasi, Giovanni; Vitabile, Salvatore; Russo, Giorgio/titolo:A computational study on temperature variations in mrgfus treatments using prf thermometry techniques and optical probes/doi:10.3390%2Fjimaging7040063/rivista:JOURNAL OF IMAGING/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:7 Volume 7 Issue 4 |
| ISSN: | 2313-433X |
| Popis: | Structural and metabolic imaging are fundamental for diagnosis, treatment and follow-up in oncology. Beyond the well-established diagnostic imaging applications, ultrasounds are currently emerging in the clinical practice as a noninvasive technology for therapy. Indeed, the sound waves can be used to increase the temperature inside the target solid tumors, leading to apoptosis or necrosis of neoplastic tissues. The Magnetic resonance-guided focused ultrasound surgery (MRgFUS) technology represents a valid application of this ultrasound property, mainly used in oncology and neurology. In this paper patient safety during MRgFUS treatments was investigated by a series of experiments in a tissue-mimicking phantom and performing ex vivo skin samples, to promptly identify unwanted temperature rises. The acquired MR images, used to evaluate the temperature in the treated areas, were analyzed to compare classical proton resonance frequency (PRF) shift techniques and referenceless thermometry methods to accurately assess the temperature variations. We exploited radial basis function (RBF) neural networks for referenceless thermometry and compared the results against interferometric optical fiber measurements. The experimental measurements were obtained using a set of interferometric optical fibers aimed at quantifying temperature variations directly in the sonication areas. The temperature increases during the treatment were not accurately detected by MRI-based referenceless thermometry methods, and more sensitive measurement systems, such as optical fibers, would be required. In-depth studies about these aspects are needed to monitor temperature and improve safety during MRgFUS treatments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|