Sensitive and Specific Protein Sensing Using Single-Mode Tapered Fiber Immobilized With Biorecognition Molecules
| Autor: | Mohd Adzir Mahdi, Mohd Hanif Yaacob, M. H. Abu Bakar, Amir Syahir, Y. Mustapha Kamil, M. A. Mustapa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Specific protein
lcsh:Applied optics. Photonics Materials science Single-mode optical fiber lcsh:TA1501-1820 Nanotechnology tapered microfiber biosensors Atomic and Molecular Physics and Optics Highly sensitive Molecule biophotonics instrumentation lcsh:QC350-467 Fiber Sensitivity (control systems) Electrical and Electronic Engineering Biosensor Refractive index refractive-index sensor lcsh:Optics. Light |
| Zdroj: | IEEE Photonics Journal, Vol 7, Iss 6, Pp 1-9 (2015) |
| ISSN: | 1943-0655 |
| Popis: | We examine and demonstrate a biosensor using single-mode tapered fiber that has been immobilized with biorecognition molecules to sense targeted proteins. Interaction of evanescent waves with the external medium surrounding the tapered region produces an interferometric-patterned spectrum, which shifts correspondingly to any changes of refractive index (RI) in the external medium. The proposed setup managed to obtain an RI sensitivity and concentration sensitivity of 2526.8 nm/RIU and 20.368 nm/μM, respectively, which, to our knowledge, is highly sensitive when compared with previous studies. The dynamic performance, good specificity, and high sensitivity of the proposed method highlight an immensely beneficial choice for immunological diagnostics. |
| Databáze: | OpenAIRE |
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