Comparative study of clinicopathological significance, BIRC7, and STC2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder
| Autor: | Li Dq, Liang Lf, Zeng Gx, Zou Q, Yang Zl, Yuan Y, Chen Sl, Li Jh |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adenosquamous carcinoma Adenocarcinoma Gastroenterology Metastasis Inhibitor of Apoptosis Proteins Immunoenzyme Techniques Carcinoma Adenosquamous Internal medicine medicine Biomarkers Tumor Humans Gallbladder cancer Stage (cooking) Pathological Adaptor Proteins Signal Transducing Aged Glycoproteins Neoplasm Staging Aged 80 and over business.industry Gallbladder Middle Aged medicine.disease Prognosis Neoplasm Proteins Survival Rate medicine.anatomical_structure Oncology Lymphatic Metastasis Carcinoma Squamous Cell Immunohistochemistry Intercellular Signaling Peptides and Proteins Female Gallbladder Neoplasms Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | Neoplasma. 60(6) |
| ISSN: | 0028-2685 |
| Popis: | Background The differences in clinical, pathological, and biological characteristics between adenocarcinoma (AC) and squamous cell/adenosquamous carcinoma (SC/ASC) of gallbladder cancer have not been well documented. This study is to compare the clinicopathological characteristics and FGFBP1 and WISP-2 expression between AC and SC/ ASC patients. Methods We examined FGFBP1 and WISP-2 expression in 46 SC/ASC and 80 AC samples using immunohistochemistry and analyzed their correlations with clinicopathological characteristics. Results SC/ASCs occur more frequently in older patients and often correspond to larger tumor masses than ACs. Positive FGFBP1 and negative WISP-2 expression were significantly associated with lymph node metastasis and invasion of SC/ASCs and ACs. In addition, positive FGFBP1 and negative WISP-2 expression were significantly associated with differentiation and TMN stage in ACs. Univariate Kaplan‐Meier analysis showed that either elevated FGFBP1 (p \ 0.001) or lowered WISP-2 (p \ 0.001) expression was closely associated with decreased overall survival in both SC/ASC and AC patients. Multivariate Cox regression analysis showed that positive FGFBP1 expression (p = 0.001) or negative WISP-2 expression (p = 0.035 for SC/ASC and p = 0.009 for AC) is an independent predictor of poor prognosis in both SC/ASC and AC patients. We also revealed that differentiation, tumor size, TNM stage, lymph node metastasis, invasion, and surgical procedure were associated with survival of both SC/ASC and AC patients. Conclusion Our study suggested that the overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|