Evaluation of peri-infarcted hypoperfusion with T2*-weighted dynamic MRI
| Autor: | Norihiro Sadato, Yoshiharu Yonekura, Chika Tsuchida, Tsuyoshi Matsuda, Ishii Y, Yasutaka Kawamura, Nobushige Hayashi, Hiroki Yamada, Kazutaka Yamamoto, Masayuki Maeda |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Infarction Perfusion scanning Single-photon emission computed tomography Sensitivity and Specificity Brain Ischemia Diagnosis Differential medicine Humans Radiology Nuclear Medicine and imaging Cerebral perfusion pressure Aged Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Cerebral infarction Brain Cerebral Infarction Middle Aged Image Enhancement medicine.disease Magnetic Resonance Imaging Cerebral blood flow Evaluation Studies as Topic Dynamic contrast-enhanced MRI Female Radiology business Nuclear medicine Perfusion |
| Zdroj: | Journal of Magnetic Resonance Imaging. 7:518-522 |
| ISSN: | 1522-2586 1053-1807 |
| DOI: | 10.1002/jmri.1880070311 |
| Popis: | The purpose of this study was to evaluate cerebral perfusion with T2*-weighted dynamic MRI in the area around the infarcted core. We examined seven patients with subacute cerebral infarction. After bolus injection a gadopentetate dimeglumine, a series of gradient-echo images were recorded in a selected slice. From these images, concentration-time curves were created on a region-of-interest (ROI) basis around infarction for calculating relative regional cerebral blood volume (rrCBV). Brain perfusion single photon emission computed tomography (SPECT) study also was performed with intravenous injection of 123I-labeled N-isopropyl-p-iodoamphetamine (123I-IMP). All patients showed prolonged signal decrease in the area around the infarcted core. ROI analysis showed significantly increased rrCBV compared to the normal side (P < .01, paired t test). The 123I-IMP SPECT study showed that these areas had decreased cerebral blood flow. Theses findings suggest compensatory vascular dilatation due to decreased perfusion pressure. T2*-weighted dynamic MRI is a useful method for detecting compensatory vasodilatation of ischemic insult in the peri-infarcted area. |
| Databáze: | OpenAIRE |
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