Preliminary assessment of the epithelial nuclear-cytoplasmic ratio and nuclear volume density in human palatal lesions
| Autor: | F. H. White, L. J. Yang, Yan Jin |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cytoplasm
Cancer Research Pathology medicine.medical_specialty Hyperkeratosis Biology Malignancy Epithelium Pathology and Forensic Medicine Basal (phylogenetics) Image Processing Computer-Assisted medicine Humans Neoplasm Invasiveness Oral mucosa Retrospective Studies Cell Nucleus Stomatitis Hyperplasia Palatal Neoplasms Papilloma Palate Carcinoma Mouth Mucosa Reproducibility of Results Prognosis medicine.disease Cell Transformation Neoplastic medicine.anatomical_structure Otorhinolaryngology Dysplasia Carcinoma Squamous Cell Squamous cell papilloma Periodontics Mouth Neoplasms Hard palate Leukoplakia Oral Oral Surgery Mouth Diseases |
| Zdroj: | Journal of Oral Pathology and Medicine. 24:261-265 |
| ISSN: | 1600-0714 0904-2512 |
| DOI: | 10.1111/j.1600-0714.1995.tb01179.x |
| Popis: | We have analysed both the nuclear-cytoplasmic (N/C) ratio and nuclear volume densities (VVN) in defined strata from human hard palate lesions with and without malignant potential to determine the prognostic reliability and/or validity of this parameter. Measurements of cellular and nuclear areas of basal and spinous cells from normal (N) and pathological palatal epithelium were made on histological sections using an image analyser. The lesions comprised fibrous hyperplasia (FH), traumatic inflammation (INF), benign hyperkeratosis (HK), squamous cell papilloma (PP), dysplastic epithelium adjacent to invasive carcinoma (CE) and islands of invasive squamous cell carcinoma (CI). In basal cells, no significant differences were detected in comparisons of N/C and VVN between all pathological groups and the N control group. The mean value for CE was lower than that obtained for N. In spinous cells, the only statistically significant comparison was between IF and FH for both N/C and VVN. Both parameters were lower in CE than in N. Of all groups analysed except CI, the CE group is the only one likely to possess an increased malignant potential. The N/C ratio therefore seems to be of no value as a predictor of malignancy in palatal epithelial lesions. |
| Databáze: | OpenAIRE |
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