Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear
| Autor: | Jennifer Hou, Jared J. Hartsock, Alec N. Salt, Fabrice Piu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Human ear Triamcinolone acetonide intratympanic therapy dexamethasone Pharmacology triamcinolone triamcinolone acetonide lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Pharmacokinetics idiopathic sudden sensorineural hearing loss medicine otorhinolaryngologic diseases Distribution (pharmacology) Inner ear Meniere’s disease lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Dexamethasone Original Research Chemistry Perilymph medicine.disease 3. Good health 030104 developmental biology medicine.anatomical_structure sense organs 030217 neurology & neurosurgery Meniere's disease medicine.drug Neuroscience |
| Zdroj: | Frontiers in Cellular Neuroscience, Vol 13 (2019) Frontiers in Cellular Neuroscience |
| ISSN: | 1662-5102 |
| DOI: | 10.3389/fncel.2019.00347/full |
| Popis: | Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolone-acetonide, triamcinolone, and dexamethasone, each delivered as crystalline suspensions to guinea pigs. Triamcinolone-acetonide is a widely used form of the drug with molecular properties that allow it to readily permeate biological barriers. When applied intratympanically triamcinolone-acetonide entered perilymph rapidly but was also found to be eliminated rapidly from perilymph. The rapid rate of elimination severely limits the apical distribution of the drug when applied locally, making it unsuitable for use in the ear. In contrast, triamcinolone, rather than triamcinolone-acetonide, is a more polar form of the molecule, with higher aqueous solubility but calculated to pass less-readily through biological boundaries. Perilymph concentrations generated with intratympanic applications of triamcinolone were comparable to those with triamcinolone-acetonide but elimination measurements showed that triamcinolone was retained in perilymph longer than triamcinolone-acetonide or dexamethasone. The slower elimination is projected to result in improved distribution of triamcinolone toward the cochlear apex, potentially allowing higher drug levels to reach the speech frequency regions of the human ear. These measurements show that triamcinolone could constitute an attractive additional treatment option for local therapy of auditory disorders. |
| Databáze: | OpenAIRE |
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