Role for Periodontal Bacteria in Cardiovascular Diseases
| Autor: | Wen Chen, In-chol Kang, Howard K. Kuramitsu, Mingshan Qi |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Cell physiology
Lipopolysaccharide Arteriosclerosis Matrix metalloproteinase Cell Line Periodontal pathogen Microbiology Mice chemistry.chemical_compound Multienzyme Complexes Bacteroidaceae Infections Animals Humans Medicine NADH NADPH Oxidoreductases Porphyromonas gingivalis Cells Cultured Chemokine CCL2 Periodontal Diseases Foam cell biology business.industry Macrophages Cell Membrane Fibrous cap Cholesterol LDL General Medicine biology.organism_classification medicine.anatomical_structure Matrix Metalloproteinase 9 chemistry Cardiovascular Diseases Enzyme Induction Vacuoles Immunology Endothelium Vascular business Bacterial outer membrane Oxidation-Reduction Foam Cells |
| Zdroj: | Annals of Periodontology. 6:41-47 |
| ISSN: | 1553-0841 |
| DOI: | 10.1902/annals.2001.6.1.41 |
| Popis: | Several epidemiological studies as well as a recent animal model approach have suggested a role for periodontal diseases in the development of cardiovascular disease (CVD). This relationship could be mediated by inflammatory responses induced by periodontal pathogens as well as direct interaction of these organisms with cardiac tissue.In order to explore these possibilities, the effects of the periodontal pathogen Porphyromonas gingivalis on cellular events proposed to play a role in CVD were investigated.P. gingivalis, as well as its outer membrane vesicles (OMV), was able to induce foam cell formation (an important characteristic of CVD) in the murine macrophage cell line J774 A.1. This property appears to be mediated by the lipopolysaccharide (LPS) fraction of the cells. Several other oral bacteria were also able to induce foam cell formation. Furthermore, since the rupture of the fibrous cap of plaque appears to be an important factor in acute coronary syndrome, it was demonstrated that P. gingivalis 381 degraded fibrous caps isolated from autopsy samples. In addition, it was observed that strain 381 strongly induced matrix metalloproteinase (MMP)-9 protease activity, implicated in plaque rupture, from the J774 A.1 macrophages. Finally, strain 381 was able to enhance monocyte chemoattractant protein-1 (MCP-1) and NADH oxidase expression from endothelial cells.Therefore, P. gingivalis exhibits several properties which could play a role in CVD as mediators of LDL oxidation, foam cell formation, and rupture of atherosclerotic plaque. |
| Databáze: | OpenAIRE |
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