LPL protein in Chronic Lymphocytic Leukaemia have different origins in Mutated and Unmutated patients. Advances for a new prognostic marker in CLL
| Autor: | Mirta Giordano, Guillermo Dighiero, Angimar Uriepero, Thaïs Souto-Padrón, Victoria Irigoin, Raul Gabus, Cecilia Guillermo, Noé Seija, Pablo Oppezzo, Daniel Prieto, Carolina Oliver, Marcelo A. Navarrete, Ana Inés Landoni |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
CIENCIAS MÉDICAS Y DE LA SALUD Inmunología Endogeny Biology Gene Expression Regulation Enzymologic Flow cytometry 03 medical and health sciences 0302 clinical medicine IGHV PROFILE immune system diseases hemic and lymphatic diseases Biomarkers Tumor Extracellular medicine PROGNOSTIC MARKER Humans RNA Messenger RNA Neoplasm Aged Messenger RNA Lipoprotein lipase medicine.diagnostic_test Gene Expression Regulation Leukemic digestive oral and skin physiology nutritional and metabolic diseases Hematology purl.org/becyt/ford/3.1 [https] Middle Aged Prognosis Subcellular localization Leukemia Lymphocytic Chronic B-Cell Neoplasm Proteins Lipoprotein Lipase Medicina Básica CHRONIC LYMPHOCYTIC LEUKAEMIA 030220 oncology & carcinogenesis FLOW CYTOMETRY Cancer research biology.protein Female lipids (amino acids peptides and proteins) purl.org/becyt/ford/3 [https] Antibody LPL IGHV@ 030215 immunology |
| Zdroj: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| DOI: | 10.1111/bjh.15427 |
| Popis: | Lipoprotein lipase (LPL) mRNA expression in chronic lymphocytic leukaemia (CLL) is associated with an unmutated immunoglobulin profile and poor clinical outcome. We evaluated the subcellular localization of LPL protein in CLL cells that did or did not express LPL mRNA. Our results show that LPL protein is differently located in CLL cells depending on whether it is incorporated from the extracellular medium in mutated CLL or generated de novo by leukaemic cells of unmutated patients. The specific quantification of endogenous LPL protein correlates with mRNA expression levels and mutational IGHV status, suggesting LPL protein as a possible reliable prognostic marker in CLL. Fil: Prieto, Daniel. Instituto Pasteur de Montevideo; Uruguay. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay Fil: Seija, Noé. Universidad de la República; Uruguay. Instituto Pasteur de Montevideo; Uruguay Fil: Uriepero, Angimar. Instituto Pasteur de Montevideo; Uruguay Fil: Souto-Padron, Thais. Universidade Federal do Rio de Janeiro; Brasil Fil: Oliver, Carolina. Universidad de la República; Uruguay Fil: Irigoin, Victoria. Universidad de la República; Uruguay Fil: Guillermo, Cecilia. Universidad de la República; Uruguay Fil: Navarrete, Marcelo A.. Universidad de Magallanes; Chile Fil: Inés Landoni, Ana. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay Fil: Dighiero, Guillermo. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay Fil: Gabus, Raúl. Ministerio de Salud. Administración Servicios de Salud del Estado. Hospital Maciel; Uruguay Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina Fil: Oppezzo, Pablo. Instituto Pasteur de Montevideo; Uruguay |
| Databáze: | OpenAIRE |
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