Metabolism and nephrotoxicity of indan in male Fischer 344 rats
| Autor: | D. W. Hobson, C T Olson, M. P. Servé, M J Ferry, Kyung O. Yu |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Chromatography Metabolite Indane Kidney metabolism Administration Oral Metabolism Toxicology medicine.disease Kidney Pollution Gas Chromatography-Mass Spectrometry Rats Inbred F344 Nephropathy Nephrotoxicity Rats chemistry.chemical_compound chemistry Indenes Indans medicine Animals Gas chromatography Gas chromatography–mass spectrometry |
| Zdroj: | Journal of toxicology and environmental health. 29(4) |
| ISSN: | 0098-4108 |
| Popis: | Indan, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1-indanol, 2-indanol, 5-indanol, 1-indanone, 2-indanone, 2-hydroxy-1-indanone, cis-1,2-indandiol, and trans-1,2-indandiol. The metabolites were identified using the techniques of gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The rats treated with indan demonstrated the classic lesions of hydrocarbon-induced nephropathy. The kidney damage produced was less than that found for tetralin and other branched-chain acyclic hydrocarbons. |
| Databáze: | OpenAIRE |
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