Ability to Overcome the Thrombocyte Resistance to Acetylsalicylic Acid in Patients With Coronary Artery Disease After Myocardial Revascularization With Coronary Stenting
| Autor: | D M Ramazanov, E V Sokryukina, L V Shulzhenko, S N Scherbo, Talantbek Batyraliev, Sidorenko Ba, I V Pershukov, N V Bosak, A A Omarov, T N Kuznetsova, R K Kalmatov, Zarema Karben, S L Ostaschenko |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Myocardial revascularization Platelet Aggregation Platelet aggregation medicine.medical_treatment Drug Resistance Coronary Artery Disease Coronary artery disease Angioplasty Internal medicine Humans Medicine Platelet In patient Angioplasty Balloon Coronary Enteric coated Aged Aged 80 and over Aspirin business.industry Coronary stenting Middle Aged medicine.disease digestive system diseases surgical procedures operative Cardiology Female Stents Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors |
| Zdroj: | Kardiologiia. :5-9 |
| ISSN: | 0022-9040 |
| Popis: | Resistance to acetylsalicylic acid (ASA) in patients with coronary artery disease is a poor predictor for the development of atherothrombotic complications. In 277 patients with coronary artery disease suffered uncomplicated coronary angioplasty with stent implantation, we was estimated arachidon-induced platelet aggregation during treatment with acetylsalicylic acid by bedside VerifyNow Assay test at 28-90 days after the intervention. It was found that 18.9% of the 144 patients receiving a combination of ASA 75 mg with 15.2 mg of magnesium hydroxide had true (laboratory) resistance to ASA. At the same time on the original enteric coated ASA 100 mg, we can found only 0.8% resistance to ASA among 129 patients. We made switch from combination of ASA 75 mg with 15.2 mg of magnesium hydroxide to original enteric coated ASA 100 mg and repeat VerifyNow Assay test at 2-4 days and found lost of resistance in 92% of 28 patients. Thus, resistance to the ASA is not constant, it depends on the form and the applied dose of ASA, and eliminating more than 92% when ASA changes from ineffective to effective form. |
| Databáze: | OpenAIRE |
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