Chemical and biological effects associated with the iodination of angiotensin II

Autor:	A. Coli, L. Vancheri, U. Rosa, H. Kurcbart
Rok vydání:	1971
Předmět:	Hormonal activity Chemical Phenomena Chromatography Paper Colon Angiotensin II Biophysics chemistry.chemical_element Halogenation Iodine Biochemistry Medicinal chemistry Chemistry Residue (chemistry) chemistry Renin–angiotensin system Molecular Biology
Zdroj:	Biochimica et Biophysica Acta (BBA) - General Subjects. 230:160-169
ISSN:	0304-4165
DOI:	10.1016/0304-4165(71)90063-8
Popis:	Angiotensin II has been allowed to react with varying amounts of iodine under mild conditions (electrolytic iodination). The trosyl residue can be converted to monoiodotyrosyl with a minimal loss of the hormonal activity. On the contrary the diiodinated derivative is almost completely inactivated. The yields of monoiodinated and diiodinated angiotensin at increasing degress of iodination depend on the reaction pH. Under appropriate experimental conditions, it is possible to prepare radioiodine-labelled angiotensinm to act as a true tracer of the native one.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3509d40759bdfeb5b79b59a8bd8fc4 https://doi.org/10.1016/0304-4165(71)90063-8 Zobrazit plný text záznamu