Clinical Stage and Risk of Recurrence and Mortality: Interaction of Dna Methylation Factors in Patients with Colorectal Cancer
| Autor: | Jih-Fu Hsieh, Jen-Chun Kuan, Fu-Gong Lin, Chih-Hsiung Hsu, Chi-Ming Chu, Hsien-Feng Chang, Chang-Chieh Wu, Chien-An Sun, Yang-Ming Tsai, Yu-Ching Chou, Chi-Hua Huang, Tsan Yang |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Candidate gene Colorectal cancer medicine.disease_cause General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Odds Ratio medicine Humans Stage (cooking) Promoter Regions Genetic Aged Neoplasm Staging Cancer staging Clinical pathology business.industry Cancer General Medicine DNA Methylation Middle Aged medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis DNA methylation Female Neoplasm Recurrence Local Colorectal Neoplasms business Carcinogenesis |
| Zdroj: | Journal of Investigative Medicine. 64:1200-1207 |
| ISSN: | 1708-8267 1081-5589 |
| DOI: | 10.1136/jim-2016-000086 |
| Popis: | Aberrant DNA methylation plays a crucial role in cancer development; however, prospective evidence of an interaction between molecular biomarkers and cancer staging for predicting the prognosis of colorectal cancer (CRC) is still limited. We examined DNA methylation in tumors and adjacent normal tissues from patients who underwent CRC surgical resection, and evaluated the interaction between cancer staging (advanced vs local) and DNA methylation to predict the prognosis of CRC. We recruited 132 patients with CRC from Tri-Service General Hospital in Taiwan and used the candidate gene approach to select 3 tumor suppressor genes involved in carcinogenesis pathways. ORs and 95% CIs were computed using logistic regression analyses while adjusting for potential covariates. Advanced cancer stage was correlated with cancer recurrence (OR 7.22, 95% CI 2.82 to 18.45; p |
| Databáze: | OpenAIRE |
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