| Autor: |
Koji Furukawa, Atsushi Shima, Daisuke Kambe, Akira Nishida, Ikko Wada, Haruhi Sakamaki, Kenji Yoshimura, Yuta Terada, Yusuke Sakato, Masahiro Mitsuhashi, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Yasutaka Fushimi, Tomohisa Okada, Yuji Nakamoto, Ryosuke Takahashi, Nobukatsu Sawamoto |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Annals of neurologyReferences. 92(1) |
| ISSN: |
1531-8249 |
| Popis: |
The motor severity in Parkinson disease (PD) is believed to parallel dopaminergic terminal degeneration in the striatum, although the terminal was reported to be virtually absent by 4 years postdiagnosis. Meanwhile, neuromelanin-laden dopamine neuron loss in the substantia nigra (SN) elucidated a variability at early stages and gradual loss with less variability 10 years postdiagnosis. Here, we aimed to clarify the correlation between motor impairments and striatal dopaminergic terminal degeneration and nigral neuromelanin-laden dopamine neuron loss at early to advanced stages of PD.Ninety-three PD patients were divided into early and advanced subgroups based on motor symptom duration and whether motor fluctuation was present. Striatal dopaminergic terminal degeneration was evaluated using a presynaptic dopamine transporter tracer,In patients with early stage PD (motor symptoms for ≤8 or 10 years), motor dysfunction during the drug-off state was paralleled by a decline inWe propose striatal dopaminergic terminal loss measured using |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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