The role of miRNA in inflammation and autoimmunity

Autor:	Sudhir Manickavel, Deborah K. Mc Curdy, Hamida Rehimi, Satendra Singh, David T.W. Wong, Israel Massachi, Ram P. Singh, Sherven Sharma, Sascha Hasan, Nagesh Rao, Bevra H. Hahn
Rok vydání:	2013
Předmět:	Inflammation Cellular differentiation Immunology RNA Autoimmunity Biology medicine.disease_cause Autoimmune Diseases Pathogenesis MicroRNAs Immune system Gene Expression Regulation microRNA Cancer research medicine Immunology and Allergy Animals Humans medicine.symptom Gene
Zdroj:	Autoimmunity reviews. 12(12)
ISSN:	1873-0183
Popis:	miRNAs are small non-coding RNA molecules that modulate the expression of multiple protein-encoding genes at the post-transcriptional level. They have recently been recognized as powerful regulators of numerous genes and pathways in the pathogenesis of inflammatory and autoimmune diseases. The targets of most miRNAs remain unknown and their roles in biological processes such as cell differentiation, proliferation, and death (apoptosis) are not clearly understood. In this review we will discuss how certain candidate miRNAs affect inflammatory and immune mediated diseases by regulating their cellular and molecular targets. We focused the influence of gender and sex hormones on miRNA. We believe that understanding the role of miRNAs could shed light on the cause and progression of many inflammatory and autoimmune diseases and eventually lay the groundwork for therapeutic options.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3393ed0635a7a709b6c041dbc09dac https://pubmed.ncbi.nlm.nih.gov/23860189 Zobrazit plný text záznamu Full Text from ScienceDirect