MxB is an interferon-induced restriction factor of human herpesviruses
| Autor: | Karin Boucke, Jovan Pavlovic, Cornel Fraefel, Christian Münz, Michel Crameri, Urs F. Greber, Francesca D. Franzoso, Raphael Walker, Andrea Zbinden, Nicole Caduff, Fiona Steiner, Talissa Kucera, Michael Bauer, Cornelia Gujer |
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| Přispěvatelé: | Universität Zürich [Zürich] = University of Zurich (UZH), Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de la Recherche Agronomique (INRA), University of Zurich, Pavlovic, Jovan |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
10028 Institute of Medical Virology
0301 basic medicine Myxovirus Resistance Proteins Cytoplasm [SDV]Life Sciences [q-bio] viruses General Physics and Astronomy 10263 Institute of Experimental Immunology medicine.disease_cause Virus Replication chemistry.chemical_compound Interferon Virus Uncoating Gammaherpesvirinae RNA Small Interfering lcsh:Science Herpesviridae ComputingMilieux_MISCELLANEOUS Multidisciplinary biology virus diseases Viral tegument Herpesviridae Infections 10124 Institute of Molecular Life Sciences 3100 General Physics and Astronomy 3. Good health Capsid Interferon Type I 10244 Institute of Virology medicine.drug Science 1600 General Chemistry Context (language use) General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences 1300 General Biochemistry Genetics and Molecular Biology Alphaherpesvirinae Cell Line Tumor medicine Humans Cell Nucleus General Chemistry biology.organism_classification Virology 030104 developmental biology Herpes simplex virus HEK293 Cells chemistry DNA Viral 570 Life sciences Capsid Proteins lcsh:Q DNA |
| Zdroj: | Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018) Cytokine 5th Annual Meeting of the International-Cytokine-and-Interferon-Society 5th Annual Meeting of the International-Cytokine-and-Interferon-Society, Oct 2017, Kanazawa, Japan. pp.1 Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi’s sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid. MxB is an interferon-induced GTPase that inhibits HIV replication. Here, Crameri et al. show that MxB restricts replication of herpesviruses by inhibiting delivery of incoming viral DNA into the nucleus, and this antiviral activity depends on MxB’s GTPase activity. |
| Databáze: | OpenAIRE |
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