Diagnostic value of circulating microRNA-208a in differentiation of preserved from reduced ejection fraction heart failure
| Autor: | Bin-Xin Li, Dong-Mei Li, Zhong-Juan Li, Li-Jie Yang, Zhong-Yu Ma, Peng Gao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Prohormone 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine 03 medical and health sciences 0302 clinical medicine Internal medicine Healthy volunteers Area under curve Natriuretic Peptide Brain Medicine Humans Circulating MicroRNA Heart Failure Ejection fraction business.industry Stroke Volume medicine.disease Brain natriuretic peptide Peptide Fragments MicroRNAs 030228 respiratory system Heart failure Cardiology Biomarker (medicine) Cardiology and Cardiovascular Medicine business Biomarkers medicine.drug |
| Zdroj: | Heartlung : the journal of critical care. 50(1) |
| ISSN: | 1527-3288 |
| Popis: | There is no satisfactory answer on the specific biomarker that might be used in differentiating heart failure with reduced EF (HFrEF), allowing for inadequacy of N-terminal prohormone brain natriuretic peptide (NT-proBNP).We aim to evaluate the value of microRNA-208a in diagnosing HFrEF patients.We included 120 HF patients and 60 healthy volunteers. Diagnostic values of NT-proBNP and miR-208a for HF patients versus controls and HFrEF versus HFpEF were described by area under curve (AUC), sensitivity and specificity.HFrEF patients had significantly higher miR-208a level (p0.001). As for diagnosing HFrEF patients, additional use of miR-208a and NT-proBNP yielded a significantly higher AUC than NT-proBNP alone (0.83, 95% CI 0.76-0.90 vs. 0.73, 95% CI 0.64-0.82) and the sensitivity and specificity were raised to 68.0% and 90.2%.Use of miR-208a in combination with NT-proBNP may allow a more reliable method in diagnosing HFrEF patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect