The frequency of HIV-specific interferon- gamma -producing CD8 T cells is associated with both age and level of antigenic stimulation in HIV-1-infected children
| Autor: | Florence Buseyne, Marianne Burgard, Daniel Scott-Algara, Nassima Bellal, C. Rouzioux, Stéphane Blanche, Yves Rivière |
|---|---|
| Přispěvatelé: | Immunopathologie Virale, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Biologie des Rétrovirus, Institut Pasteur [Paris], Laboratoire de Virologie [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Fédération de Pédiatrie, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP] |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Male
Aging MESH: CD4 Lymphocyte Count viruses Retroviridae Proteins HIV Infections MESH : Viral Load CD8-Positive T-Lymphocytes MESH : Child Preschool Lymphocyte Activation MESH: Antiretroviral Therapy Highly Active MESH: HIV-1 0302 clinical medicine MESH : Child Interferon Antiretroviral Therapy Highly Active MESH: Child Immunology and Allergy Cytotoxic T cell MESH : Female Interferon gamma MESH: Aging Child 0303 health sciences biology MESH: Infant Newborn virus diseases MESH : Infant MESH : Interferon Type II MESH: HIV Infections Viral Load MESH : Adult MESH : CD8-Positive T-Lymphocytes MESH: Infant MESH: CD8-Positive T-Lymphocytes 3. Good health Infectious Diseases Child Preschool MESH: RNA Viral Lentivirus RNA Viral Female Viral disease MESH: Viral Load Viral load MESH : HIV-1 medicine.drug Adult Adolescent MESH: Interferon Type II MESH : Male MESH : Infant Newborn Virus Interferon-gamma 03 medical and health sciences MESH : Retroviridae Proteins Antigen MESH : Adolescent MESH : CD4 Lymphocyte Count MESH : HIV Infections medicine Humans MESH : RNA Viral MESH: Lymphocyte Activation MESH : Lymphocyte Activation 030304 developmental biology MESH: Adolescent MESH: Humans MESH : Humans MESH: Child Preschool Infant Newborn Infant MESH: Adult MESH: Retroviridae Proteins MESH : Antiretroviral Therapy Highly Active biology.organism_classification Virology MESH : Aging MESH: Male CD4 Lymphocyte Count Immunology HIV-1 MESH: Female 030215 immunology |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2005, 192 (10), pp.1781-6. ⟨10.1086/497152⟩ Journal of Infectious Diseases, 2005, 192 (10), pp.1781-6. ⟨10.1086/497152⟩ Journal of Infectious Diseases, Oxford University Press (OUP), 2005, 192 (10), pp.1781-6. 〈10.1086/497152〉 |
| ISSN: | 0022-1899 1537-6613 |
| Popis: | Ex vivo interferon (IFN)- gamma -producing CD8 T cells specific for human immunodeficiency virus (HIV) Env, Gag, and Pol antigens were measured in the peripheral blood of 55 children not receiving highly active antiretroviral therapy (HAART) and 70 children receiving HAART. In children not receiving HAART, the frequency of HIV-specific IFN- gamma -producing CD8 T cells was positively correlated with age and was not associated with plasma viral load or CD4 T cell levels. In children receiving HAART, the frequency of HIV-specific IFN- gamma -producing CD8 T cells was directly correlated with plasma viral load, and its association with age remained significant. In conclusion, the frequency of HIV-specific IFN- gamma -producing CD8 T cells in children is primarily determined by both age and plasma viral load. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|