In vitro antifungal resistance of oral Candida albicans strains in non-AIDS Patients
| Autor: | I. Madinier, R. A. Monteil, Y. Le Fichoux |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Azoles
Male Microbiology (medical) Antifungal Antifungal Agents medicine.drug_class Immunology Flucytosine Microbial Sensitivity Tests Polyenes Biology Microbiology Cohort Studies Minimum inhibitory concentration Candidiasis Oral HIV Seronegativity Candida albicans medicine Humans General Dentistry Mycosis Aids patients Dose-Response Relationship Drug Drug Resistance Microbial Fungi imperfecti Middle Aged biology.organism_classification medicine.disease Corpus albicans In vitro Female |
| Zdroj: | Oral Microbiology and Immunology. 12:126-128 |
| ISSN: | 1399-302X 0902-0055 |
| DOI: | 10.1111/j.1399-302x.1997.tb00629.x |
| Popis: | Some cases of oral candidosis are refractory to antifungal treatment. This might be related to development of resistant Candida strains, but susceptibility testing is not standardized and not routinely available, and information related to this problem is scarce in non-AIDS patients. In this study, the in vitro antifungal resistance of oral Candida albicans strains was evaluated. The strains were obtained from a cohort of 72 HIV-negative patients with oral yeast carriage and clinical complaint. Laboratory identification revealed C. albicans in 93% of cases. None of these oral C. albicans isolates showed in vitro resistance to polyenes, but they showed varying resistance levels to fluorocytosine and azoles. This study confirms the usefulness of standardizing susceptibility testing so that it could be routinely available and of realizing a mycological diagnosis including an antifungigram when oral candidosis is suspected, whenever antifungal treatment with azoles is planned. |
| Databáze: | OpenAIRE |
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