Investigation of 5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione as a Matrix for Analyses of Biogenic Monoamine Transmitters Using MALDI-MS
| Autor: | Unno Yumi, Yuzo Yamazaki, Masayoshi Tsubuki, Tomomi Sugita, Hiroki Nakajima, Hiroko F. Kasai, Mayu Matsuoka, Hideshi Fujiwake, Masamichi Nakakoshi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neurotransmitter Agents Maldi ms Chromatography Chemistry 010401 analytical chemistry Mass spectrometry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Analytical Chemistry 03 medical and health sciences Matrix (mathematics) 030104 developmental biology Monoamine neurotransmitter Dopamine Desorption Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization medicine Biogenic Monoamines Thiazolidinediones Serotonin Thiazolidine 2 4 dione medicine.drug |
| Zdroj: | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 32(8) |
| ISSN: | 1348-2246 |
| Popis: | In order to discover new matrices suitable for the analyses of low molecular-weight compounds using positive-ion mode matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (MS), 5-(3-trifluoromethylbenzylidene)thiazolidine-2,4-dione (3-CF3-BTD) was synthesized, and its effectiveness was compared with that when commercially available α-cyano-4-hydroxycinnamic acid was used. 3-CF3-BTD was sufficiently sensitive to analyze neurotransmitters, i.e., dopamine, serotonin, histamine, and epinephrine, in amounts of several picomoles. Similar to vacuum MALDI experiments, atmospheric-pressure MALDI-MS measurements using 3-CF3-BTD as a matrix also detected dopamine. |
| Databáze: | OpenAIRE |
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