Association of neutrophil-to-lymphocyte and lymphocyte-to-C-reactive protein ratios with COVID-19-related mortality
| Autor: | Ricardo D. González-Ríos, Guillermo Flores-Padilla, Claudia Ramírez-Rentería, Carlos Eduardo Contreras-García, Maura E. Noyola-García, Alejandra Albarrán-Sánchez, Paolo Alberti-Minutti, Luis A. Reyes-Naranjo, David J. Castillo-López, Luis E. Martínez-Ascencio, Luis A. Guízar-García, Juan Carlos Anda-Garay |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Cross-sectional study Neutrophils Lymphocyte Gastroenterology Sensitivity and Specificity Severity of Illness Index Predictive Value of Tests Internal medicine Severity of illness Medicine Humans Lymphocytes Neutrophil to lymphocyte ratio Mexico Aged biology business.industry C-reactive protein COVID-19 General Medicine Middle Aged medicine.anatomical_structure C-Reactive Protein Cross-Sectional Studies Predictive value of tests biology.protein Female Cutoff point business |
| Zdroj: | Gaceta medica de Mexico. 156(6) |
| ISSN: | 0016-3813 |
| Popis: | Neutrophil-to-lymphocyte (NLR) and lymphocyte-to-C-reactive protein (LCR) ratios are used to predict severity and mortality in various infections.To establish the best NLR and LCR cutoff point to predict mortality in patients hospitalized for COVID-19 in Mexico.Analytical cross-sectional study of patients hospitalized for severe COVID-19 in a specialty hospital.Out of 242 analyzed patients, 34 % died. The deceased subjects were older (62 vs. 51 years; p0.001), had a higher prevalence of10 years with systemic arterial hypertension (59.4 vs. 45.1 %, p = 0.022), as well as a higher NLR (17.66 vs. 8.31, p0.001) and lower LCR (0.03 vs. 0.06, p0.002) with regard to those who survived. The cutoff points to predict mortality were NLR12 and LCR0.03. The combination of NLR/LCR had a sensitivity of 80 %, specificity of 74 %, positive predictive value of 46.15 %, negative predictive value of 93.02 % and an odds ratio of 11.429 to predict mortality.NLR12 and LCR0.03 are useful biomarkers to evaluate the risk of mortality in Mexican patients with severe COVID- 19.Los índices neutrófilo/linfocito (INL) y linfocito/proteína C reactiva (ILR) se usan para predecir severidad y mortalidad en diversas infecciones.Establecer en México el mejor punto de corte de INL e ILR para predecir la mortalidad en pacientes hospitalizados por COVID-19.Estudio transversal analítico de pacientes hospitalizados por COVID-19 grave en un hospital de especialidades.Falleció 34 % de 242 pacientes analizados. Los sujetos fallecidos tenían mayor edad (62 versus 51 años, p0.001), mayor prevalencia de hipertensión arterial sistémica10 años (59.4 versus 45.1 %, p = 0.022), así como INL más alto (17.66 versus 8.31, p0.001) e ILR más bajo (0.03 versus 0.06, p0.002) respecto a quienes sobrevivieron. Los puntos de corte para predecir mortalidad fueron INL12 e ILR0.03. La combinación de INL e ILR tuvo sensibilidad de 80 %, especificidad de 74 %, valor predictivo positivo de 46.15 %, valor predictivo negativo de 93.02 % y razón de momios de 11.429 para predecir la mortalidad.INL12 e ILR0.03 son biomarcadores útiles para evaluar el riesgo de mortalidad en pacientes mexicanos con COVID-19 grave. |
| Databáze: | OpenAIRE |
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