Curvature induces active velocity waves in rotating spherical tissues

Autor: Tom Brandstätter, David B. Brückner, Yu Long Han, Ricard Alert, Ming Guo, Chase P. Broedersz
Přispěvatelé: LaserLaB - Molecular Biophysics, Physics of Living Systems, LaserLaB - Energy
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, 14(1):1643, 1-11. Nature Publishing Group
Brandstätter, T, Brückner, D B, Han, Y L, Alert, R, Guo, M & Broedersz, C P 2023, ' Curvature induces active velocity waves in rotating spherical tissues ', Nature Communications, vol. 14, no. 1, 1643, pp. 1-11 . https://doi.org/10.1038/s41467-023-37054-2
ISSN: 2041-1723
Popis: The multicellular organization of diverse systems, including embryos, intestines, and tumors relies on coordinated cell migration in curved environments. In these settings, cells establish supracellular patterns of motion, including collective rotation and invasion. While such collective modes have been studied extensively in flat systems, the consequences of geometrical and topological constraints on collective migration in curved systems are largely unknown. Here, we discover a collective mode of cell migration in rotating spherical tissues manifesting as a propagating single-wavelength velocity wave. This wave is accompanied by an apparently incompressible supracellular flow pattern featuring topological defects as dictated by the spherical topology. Using a minimal active particle model, we reveal that this collective mode arises from the effect of curvature on the active flocking behavior of a cell layer confined to a spherical surface. Our results thus identify curvature-induced velocity waves as a mode of collective cell migration, impacting the dynamical organization of 3D curved tissues.
Databáze: OpenAIRE
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