Role of cytokines and platelet-activating factor in microvascular immune injury
| Autor: | Monique Braquet, David Hosford, René Bourgain, Federico Bussolino, Pierre Braquet |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Lipopolysaccharides
Vasculitis Neutrophils Inflammatory response Immunology Guinea Pigs Inflammation In Vitro Techniques Antigen-Antibody Reactions chemistry.chemical_compound Biological Factors Immune system Tissue damage medicine Immunology and Allergy Animals Platelet Activating Factor Blood Cells Platelet-activating factor business.industry Tumor Necrosis Factor-alpha Microcirculation Thrombosis General Medicine Eosinophils chemistry Immune System Diseases Microscopy Electron Scanning Cytokines Endothelium Vascular medicine.symptom business Interleukin-1 |
| Zdroj: | International archives of allergy and applied immunology. 88(1-2) |
| ISSN: | 0020-5915 |
| Popis: | Inflammation is usually a tightly controlled process which confines tissue damage, prevents infection, and assists in cellular regeneration. However, if the inflammatory response becomes unregulated, this normally beneficial local event may escalate into a wider malignant activity, characterized by endothelial injury, excessive cell infiltration, and vascular leakage. Due to the ability of platelet-activating factor and tumor necrosis factor to elicit the release of each other, ‘prime’ cell responses, and influence the activity of other cytokines, we propose that these two mediators play a pivotal role in the formation of deleterious feedback cycles leading to the above endothelial damage which may underlie pathologies such as shock, sepsis, ischemia, and asthma. Platelet-activating factor antagonists such as BN 52021 inhibit the priming and other effects induced by platelet-activating factor and thus may be of therapeutic value in such conditions. |
| Databáze: | OpenAIRE |
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