Hypernatremia—A Manifestation of COVID-19: A Case Series
| Autor: | Georg Mols, Hans-Joachim Priebe, Christian W. Weißer, Ulrike Vogt, Anne K. Zink, Andrea Michelsen, Milena A. Zimmer |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Sodium medicine.medical_treatment Potassium Pneumonia Viral chemistry.chemical_element law.invention Cohort Studies Betacoronavirus Chlorides Renal Dialysis law Internal medicine medicine Humans Case Series Hospital Mortality Pandemics Aged Retrospective Studies Aged 80 and over Mechanical ventilation Hypernatremia Renal sodium reabsorption SARS-CoV-2 business.industry COVID-19 Liter General Medicine Length of Stay Middle Aged medicine.disease Respiration Artificial Intensive care unit Angiotensin II Endocrinology chemistry Case-Control Studies Fluid Therapy Female Natriuretic Agents Coronavirus Infections Respiratory Insufficiency business |
| Zdroj: | A&a Practice |
| ISSN: | 2575-3126 |
| DOI: | 10.1213/xaa.0000000000001295 |
| Popis: | We report for the first time therapy-resistant hypernatremia (plasma sodium concentration ≥150 mmol per liter) developing in 6 of 12 critically ill coronavirus disease 2019 (COVID-19) patients age 57–84 years requiring mechanical ventilation. There was no correlation between plasma sodium concentrations and sodium input. Plasma concentrations of chloride were elevated, those of potassium decreased. These findings are consistent with abnormally increased renal sodium reabsorption, possibly caused by increased angiotensin II activity secondary to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–induced downregulation of angiotensin-converting enzyme 2 (ACE2) receptors. As hypernatremia was associated with increased length of intensive care unit stay, special attention should be paid to the electrolyte status of COVID-19 patients. |
| Databáze: | OpenAIRE |
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