Interval lung cancers not detected on screening chest X-rays: How are they different?
| Autor: | Ping Hu, Paul A. Kvale, Martin C. Tammemägi, Pamela M. Marcus, Carl J. Zylak, David L. Spizarny, William G. Hocking, Martin M. Oken, John Commins, Christine D. Berg, Lawrence R. Ragard, Philip C. Prorok, Christine Cole Johnson |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Sensitivity and Specificity Article Risk Factors Prostate Internal medicine Odds Ratio medicine Humans Stage (cooking) Lung cancer Aged Neoplasm Staging Lung medicine.diagnostic_test business.industry Cancer Odds ratio Middle Aged medicine.disease Mass Chest X-Ray Confidence interval medicine.anatomical_structure Female Neoplasm Grading Chest radiograph business |
| Zdroj: | Lung Cancer. 86:41-46 |
| ISSN: | 0169-5002 |
| DOI: | 10.1016/j.lungcan.2014.07.013 |
| Popis: | The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial provides us an opportunity to describe interval lung cancers not detected by screening chest X-ray (CXR) compared to screen-detected cancers.Participants were screened for lung cancer with CXR at baseline and annually for two (never smokers) or three (ever smokers) more years. Screen-detected cancers were those with a positive CXR and diagnosed within 12 months. Putative interval cancers were those with a negative CXR screen but with a diagnosis of lung cancer within 12 months. Potential interval cancers were re-reviewed to determine whether lung cancer was missed and probably present during the initial interpretation or whether the lesion was a "true interval" cancer.77,445 participants were randomized to the intervention arm with 70,633 screened. Of 5227 positive screens from any screening round, 299 resulted in screen-detected lung cancers; 151 had potential interval cancers with 127 CXR available for re-review. Cancer was probably present in 45/127 (35.4%) at time of screening; 82 (64.6%) were "true interval" cancers. Compared to screen-detected cancers, true interval cancers were more common among males, persons with12 years education and those with a history of smoking. True interval lung cancers were more often small cell, 28.1% vs. 7.4%, and less often adenocarcinoma, 25.6% vs. 56.2% (p0.001), more advanced stage IV (30.5% vs. 16.6%, p0.02), and less likely to be in the right upper lobe, 17.1% vs. 36.1% (p0.02).True interval lung cancers differ from CXR-screen-detected cancers with regard to demographic variables, stage, cell type and location. ClinicalTrials.gov number: NCT00002540. |
| Databáze: | OpenAIRE |
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